Cancer Microenvironment and Therapeutic Implications

Tumor Pathophysiology Mechanisms and Therapeutic Strategies

  • Gianfranco Baronzio
  • Gianfranco Fiorentini
  • Christopher R. Cogle

Table of contents

  1. Front Matter
    Pages I-XV
  2. Tumor Physiopathology and Microenvironment Genesis

  3. Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization

    1. Front Matter
      Pages 79-79
    2. Gianfranco Baronzio, Isabel Freitas, Attilio Baronzio, Miriam Baronzio, Elisabetta Crespi, Paolo Antonio Netti
      Pages 81-104
    3. Giammaria Fiorentini, Maurizio Cantore, Francesco Montagnani, Alfonso Del Freo, Stefano Guadagni, Gianfranco Baronzio
      Pages 105-116
    4. Giammaria Fiorentini, Camillo Aliberti, Giorgio Benea, Francesco Montagnani, Andrea Mambrini, Pier Luigi Ballardini et al.
      Pages 117-135
    5. Michael R. Horsman, Dietmar W. Siemann
      Pages 137-156
    6. Gianfranco Baronzio, Isabel Freitas, Giammaria Fiorentini, Anna Rita Crugnola, Dieter Hager, Dino Ceppodomo et al.
      Pages 157-179
    7. Gianfranco Baronzio, Attilio Baronzio, Elisabetta Crespi, Isabel Freitas
      Pages 181-201
    8. Girolamo Ranieri, Annamaria Catino, Vittorio Mattioli, Vito Fazio, Gennaro Gadaleta Caldarola, Cosmo Damiano Gadaleta
      Pages 203-219
    9. Annika Bundscherer, Christian Hafner
      Pages 221-240
  4. Back Matter
    Pages 241-242

About this book


In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology.

This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.

The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.


angiogenesis cancer carcinogenesis cell chemotherapy hematology hyperthermia inflammation oncology pathogenesis pathology pathophysiology radiotherapy stem cell tumor

Editors and affiliations

  • Gianfranco Baronzio
    • 1
  • Gianfranco Fiorentini
    • 2
  • Christopher R. Cogle
    • 3
  1. 1.Legnano (Mi) and Radiotherapy / Hyperthermia DepartmentPoliclinico di Monza20052 MonzaItaly
  2. 2.Oncology DepartmentSan Giuseppe Hospital50053 EmpoliItaly
  3. 3.University of FloridaGainesvilleUSA

Bibliographic information