Handbook on Immunosenescence

Basic Understanding and Clinical Applications

  • Tamas Fulop
  • Claudio Franceschi
  • Katsuiku Hirokawa
  • Graham Pawelec

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Methods and Models for Studying Immunosenescence

    1. Front Matter
      Pages 2-2
    2. Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi, Erika Roat, Roberta Ferraresi et al.
      Pages 29-62
    3. Qing Yu, Jyoti Misra Sen, Dennis Taub
      Pages 63-85
    4. Jeff Leips
      Pages 87-105
    5. Graham Pawelec, Jürgen Kempf, Anis Larbi
      Pages 107-115
    6. Ian C. Brett, Bert E. Johansson
      Pages 117-130
    7. Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba
      Pages 131-144
    8. A. A. Romanyukha, S. G. Rudnev, T. A. Sannikova, A. I. Yashin
      Pages 145-163
  3. Cellular Immunosenescene - T Cells

    1. Front Matter
      Pages 166-166
    2. David L Lamar, Cornelia M. Weyand, Jörg J. Goronzy
      Pages 167-192
    3. Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa
      Pages 203-218
    4. Ewa Sikora, Agnieszka Brzezińska
      Pages 277-290
    5. Eric T. Clambey, John W. Kappler, Philippa Marrack
      Pages 291-325
    6. Piotr Trzonkowski
      Pages 343-377
    7. Cellular Immunosenescence - B Cells

      1. Daniela Frasca, Richard L. Riley, Bonnie B. Blomberg
        Pages 381-391
      2. Jean L. Scholz, William J. Quinn III, Michael P. Cancro
        Pages 393-413
      3. Kate L. Gibson, Deborah K. Dunn-Walters
        Pages 415-435
    8. Cellular Immunosenescence - Neutrophils

      1. Peter Uciechowski, Lothar Rink
        Pages 439-455
      2. Carl F. Fortin, Anis Larbi, Gilles Dupuis, Tamas Fulop
        Pages 457-474
      3. Janet M. Lord, Anna C. Phillips, Wiebke Arlt
        Pages 475-495
    9. Cellular Immunosenescence - Antigen Presenting Cells

      1. Anshu Agrawal, Sudhanshu Agrawal, Sudhir Gupta
        Pages 499-509
      2. Lia Ginaldi, Massimo De Martinis
        Pages 511-528
    10. Cellular Immunosenescence - NK and NKT Cells

      1. Raquel Tarazona, Inmaculada Gayoso, Corona Alonso, Corona Alonso, Esther Peralbo, Javier G. Casado et al.
        Pages 531-544
      2. Hideto Tamura, Kiyoyuki Ogata
        Pages 545-559
    11. Cellular Immunosenescence - Stem Cells

      1. Hartmut Geiger, Gary Van Zant
        Pages 573-588
    12. Cellular Immunosenescence - Genetics

      1. Elissaveta Naumova, Milena Ivanova
        Pages 615-629
      2. Owen A. Ross, Kelly M. Hinkle, I. Maeve Rea
        Pages 631-658
      3. Carmela Rita Balistreri, Giuseppina Candore, Giuseppina Colonna-Romano, Maria Paola Grimaldi, Domenico Lio, Florinda Listì et al.
        Pages 659-671
  4. Mechanisms - Receptors and Signal Transduction

    1. Front Matter
      Pages 674-674
    2. Tamas Fulop, Gilles Dupuis, Carl Fortin, Anis Larbi
      Pages 675-694
    3. Mechanisms - Mitochondria

      1. Pazit Beckerman, Arie Ben Yehuda
        Pages 713-726
    4. Mechanism - Proteasome

      1. Bertrand Friguet
        Pages 729-749
    5. Mechanisms - Cytokines

      1. Elizabeth M. Gardner, Donna M. Murasko
        Pages 753-770
      2. Susan E. McNerlan, Marilyn Armstrong, Owen A. Ross, I. Maeve Rea
        Pages 771-781
    6. Mechanisms - Neuro-Endocrine-Immune Network

      1. K. Hirokawa, M. Utsuyama
        Pages 785-798
      2. Christian R. Gomez, Vanessa Nomellini, Elizabeth J. Kovacs
        Pages 799-831
      3. Moisés E. Bauer, Cristina M. Moriguchi Jeckel, Cristina Bonorino, Flávia Ribeiro, Clarice Luz
        Pages 833-862
    7. Mechanisms- Thymus

      1. Frances T. Hakim
        Pages 865-889
    8. Mechanisms- Inflammation

      1. L. Bucci, R. Ostan, M. Capri, S. Salvioli, E. Cevenini, L. Celani et al.
        Pages 893-918
      2. Carlos Sebastián, Jorge Lloberas, Antonio Celada
        Pages 919-945

About this book


“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”


Antigen Immunosenescence and clinical applications Thymus aging cancer frailty infections metabolic syndrome senescence

Editors and affiliations

  • Tamas Fulop
    • 1
  • Claudio Franceschi
    • 2
  • Katsuiku Hirokawa
    • 3
  • Graham Pawelec
    • 4
  1. 1.Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada
  2. 2.Department of Experimental PathalogyCIG Interdepartmental Center “L. Galvani” University of BolognaBolognaItaly
  3. 3.Institute for Health and Life SciencesBunkyo-ku, TokyoJapan
  4. 4.ZMF - Zentrum Med. Forschung Abt. Transplant./ ImmunologieUniversity of TübingenTübingenGermany

Bibliographic information