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Oxidants in Biology

A Question of Balance

  • Giuseppe Valacchi
  • Paul A. Davis

Table of contents

  1. Front Matter
    Pages i-viii
  2. Old Players

    1. Albert van der Vliet, Milena Hristova, Sean McCarthy, David Kasahara
      Pages 37-66
    2. Jiřina Hofmanová, Karel Souček, Alena Vaculová, Alois Kozubík
      Pages 129-153
    3. Lucia Ciccoli, Silvia Leoncini, Cinzia Signorini, Mario Comporti
      Pages 167-181
    4. Kristy M. Powers, Larry W. Oberley, Frederick E. Domann
      Pages 183-201
    5. Francesco Cimino, Antonella Saija
      Pages 203-229
    6. Tzipora Goldkorn, Elaine M. Khan
      Pages 231-250
    7. Elisabetta Damiani, Paola Astolfi, Patricia Carloni, Pierluigi Stipa, Lucedio Greci
      Pages 251-266
  3. New Players

    1. Concetta Gardi, Beatrice Arezzini, Cinzia Signorini, Daniela Vecchio, Barbara Monaco, Mario Comporti
      Pages 315-324
  4. Back Matter
    Pages 325-327

About this book

Introduction

Oxidants, like other aspects of life, involves tradeoffs. Oxidants, whether intentionally produced or by-products of normal metabolism can either mediate a variety of critical biological processes but when present inappropriately cause extensive damage to biological molecules (DNA, proteins, and lipids). These effects can lead to either damage that is a major contributor to aging and degenerative diseases (or to other diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts) or normal physiological function- tissue repair, defense against pathogens and cellular proliferation. On the other hand the body is equipped with a complex antioxidant/oxidant handling system which includes both enzymatic and nonenzymatic (i.e. small molecules such as flavonoids, ascorbate, tocopherol, and carotenoids) produced endogenously or derived from the diet. This book focuses on how the same molecules can have favorable or noxious effects depending on location, level and timing.

Each chapter focuses on one particular molecule or oxidant/antioxidant system and provides a state of the art review of the current understanding regarding both positive and negative actions of the system under review.

Keywords

Activation DNA Diabetes Drogen Electrophile Endoplasmatisches Reticulum hydrogen peroxide lead proteins

Editors and affiliations

  • Giuseppe Valacchi
    • 1
  • Paul A. Davis
    • 2
  1. 1.Department of PhysiologyUniversity of SienaItaly
  2. 2.Department of NutritionUniversity of California DavisDavisUSA

Bibliographic information