Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

  • Paolo Beck-Peccoz

Part of the Endocrine Updates book series (ENDO, volume 22)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Michelina Plateroti, Cristina Angelin-Duclos, Frederic Flamant, Jacques Samarut
    Pages 13-33
  3. Deborah Mannavola, Paolo Beck-Peccoz
    Pages 69-88
  4. Samuel Refetoff, Peter M. Sadow, Sirimon Reutrakul, Kimberly Dennis, Deborah Mannavola, Joachim Pohlenz et al.
    Pages 89-107
  5. Fredric E. Wondisford
    Pages 109-118
  6. Luca Persani, Davide Calebiro, Tiziana de Filippis
    Pages 177-191
  7. Back Matter
    Pages 193-197

About this book

Introduction

The exponential growth in our knowledge on the pathophysiology of hypothalamic-pituitary-thyroid axis and, in particular, of thyroid hormone action, largely stems from the studies on the various syndromes of resistance to the hormones involved in the function of the axis. These syndromes essentially encompass two forms, i. e. the resistance to thyroid hormones and that to TSH action. The contribution of molecular biology has been fundamental in understanding the etiology of these different thyroid disorders and led to the discovery of new pathogenetic mechanisms, e. g. the dominant negative effects of a mutant protein on the normal one. In this book, I have assembled an internationally renewed group of experts devoted to the studies of both basic and clinical thyroidology. Taking the syndromes of resistance as a template, the novelties on the mechanisms of action of the various hormones, the etiopathogenesis of the syndromes, the instruments for the diagnosis, as well as the pitfalls in managing these diseases, are deeply revisited. The insights from different animal models are discussed, with particular focus on tissue specific action of thyroid hormones, as well as on the still enigmatic mechanism of negative feedback control of thyroid hormones on TSH secretion and the different etiologic mechanisms causing thyroid hormone resistance in patients without mutations in the thyroid hormone receptor ~. The role of the structure of thyroid hormone and TSH receptors in designing agonist or antagonist molecules is extensively debated. Moreover, new forms of congenital or acquired resistance to thyroid hormones are presented.

Keywords

hormone hormone resistance receptor thyroid hormone tissue

Editors and affiliations

  • Paolo Beck-Peccoz
    • 1
  1. 1.Institute of Endocrine Sciences, Ospedale Maggiore di Milano-IRCCSUniversity of MilanMilanItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-7852-1
  • Copyright Information Springer-Verlag US 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-1065-6
  • Online ISBN 978-1-4020-7852-1
  • Series Print ISSN 1566-0729
  • About this book