Mitochondrial Medicine

Mitochondrial Metabolism, Diseases, Diagnosis and Therapy

  • Anna Gvozdjáková

Table of contents

  1. Front Matter
    Pages i-xlv
  2. Anna Gvozdjáková
    Pages 1-17
  3. Zdenka Ďuračková, Anna Gvozdjáková
    Pages 19-54
  4. Franz Halberg, Germaine Cornélissen, Ram B. Singh, Anna Gvozdjáková, Kuniaki Otsuka, Larry Beaty et al.
    Pages 55-92
  5. Anna Gvozdjáková
    Pages 103-113
  6. Ivan Pecháň
    Pages 115-124
  7. Anna Gvozdjáková
    Pages 125-128
  8. Jozef Čársky, Anna Gvozdjáková, Miroslav Mikulecký, Jarmila Kucharská, Ram B. Singh
    Pages 129-160
  9. Katarína Gazdíková, František Gazdík
    Pages 161-187
  10. Jozef Rovenský, Karel Pavelka, Katarína Bauerová, Jarmila Kucharská
    Pages 201-246
  11. František Gazdík, Katarína Gazdíková
    Pages 247-262
  12. Anna Gvozdjáková
    Pages 263-266
  13. Jarmila Kucharská, Anna Gvozdjáková, Anna Hlavatá
    Pages 267-277
  14. Tibor Liptaj
    Pages 279-302
  15. Anna Gvozdjáková, Anna Hlavatá, Jarmila Kucharská, Patrik Palacka, Ján Murín
    Pages 323-333
  16. Anna Gvozdjáková, Jaromír Horecký, Ol'ga Vančová, Jarmila Kucharská, Katarína Bauerová, Silvester Poništ
    Pages 335-342
  17. Anna Gvozdjáková, Daniel Pella, Jarmila Kucharská, Kuniaki Otsuka, Ram B. Singh
    Pages 343-356
  18. Anna Gvozdjáková, Jarmila Kucharská, Pavol Lepieš
    Pages 357-366
  19. Jarmila Kucharská
    Pages 367-384
  20. Ján Pálinkáš, Alfonz Smola, Anna Gvozdjáková, Jarmila Kucharská
    Pages 385-398
  21. Back Matter
    Pages 399-409

About this book


Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics.

This book is based upon extensive data gathered over 30 years of clinical and experimental research. Internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mitochondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology, and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Laboratory evaluation plays a very important role in the diagnosis of mitochondrial diseases, in addition to clinical assessment. This includes analysis of plasma/mitochondrial coenzyme Q10 content, mitochondrial respiratory chain function and oxidative phosphorylation in isolated mitochondria and biopsy material, and nuclear magnetic resonance methods.

In addition to standard medical therapy to treat cardiac, CNS, and other involvements in the mitochondrial disease patients, adjunctive nutritional therapy is indicated primarily to improve mitochondrial function. Therapy include coenzyme Q10, a -lipoic acid, carnitine, w -3- and w -6-PUFA, vitamins and polarized light.

Mitochondrial Medicine is dedicated to Dr. Frederick L. Crane, discoverer of Coenzyme Q10 in 1957, and to the Celebration of 50th year of Coenzyme Q10 discovery.

This book is intended for general medical practitioners, for specialists such as cardiologists, neurologists, and diabetologists, biochemists, nutritionists, pharmacists, and also for graduate students.


assessment diagnosis neurology physiology skeletal muscle therapy

Editors and affiliations

  • Anna Gvozdjáková
    • 1
  1. 1.Comenius UniversitySlovakia

Bibliographic information

  • DOI
  • Copyright Information Springer Netherlands 2008
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine
  • Print ISBN 978-1-4020-6713-6
  • Online ISBN 978-1-4020-6714-3
  • Buy this book on publisher's site