Creatine and Creatine Kinase in Health and Disease

  • Gajja S. Salomons
  • Markus Wyss

Part of the Subcellular Biochemistry book series (SCBI, volume 46)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Olivier Braissant, Claude Bachmann, Hugues Henry
    Pages 67-81
  3. David L. Christie
    Pages 99-118
  4. Arend Heerschap, Hermien E. Kan, Christine I.H.C. Nabuurs, W. Klaasjan Renema, Dirk Isbrandt, BÉ Wieringa
    Pages 119-148
  5. Sylvia Stockler, Peter W. Schutz, Gajja S. Salomons
    Pages 149-166
  6. Andreas Schulze, Roberta Battini
    Pages 167-181
  7. Autumn M. Klein, Robert J. Ferrante
    Pages 205-243
  8. Peter Hespel, Wim Derave
    Pages 246-259
  9. Wesley Mccall, Adam M. Persky
    Pages 262-273
  10. Adam M. Persky, Eric S. Rawson
    Pages 275-289
  11. Ivo Pischel, Thomas Gastner
    Pages 291-307
  12. Markus Wyss, Olivier Braissant, Ivo Pischel, Gajja S. Salomons, Andreas Schulze, Sylvia Stockler et al.
    Pages 309-334
  13. Back Matter
    Pages 335-351

About this book

Introduction

Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand. The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the pleiotropic effects of creatine and creatine kinase, and hypothesizes on the most promising and influential future avenues of research towards creatine-based nutritional strategies for the prevention of neurological disease, and for improving the quality of life in general.

Keywords

biosynthesis metabolism pathophysiology physiology rehabilitation

Editors and affiliations

  • Gajja S. Salomons
    • 1
  • Markus Wyss
    • 2
  1. 1.VU University Medical CenterAmsterdamThe Netherlands
  2. 2.DSM Nutritional Products LtdBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-6486-9
  • Copyright Information Springer 2007
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine
  • Print ISBN 978-1-4020-6485-2
  • Online ISBN 978-1-4020-6486-9
  • Series Print ISSN 0306-0225
  • About this book