Table of contents

  1. Front Matter
    Pages I-X
  2. Daniel R. Ciocca, Mariel A. Fanelli, F. Dario Cuello-Carrión, Stuart K. Calderwood
    Pages 31-52
  3. Stuart K. Calderwood, Md Abdul Khaleque, Ajit Bharti, Daniel R. Ciocca
    Pages 53-72
  4. Vishwanie S. Budhram-Mahadeo, Richard J. Heads
    Pages 93-130
  5. María A. Bausero, Alexzander Asea
    Pages 131-140
  6. Custer C. Deocaris, Sunil C. Kaul, Renu Wadhwa
    Pages 141-158
  7. Michael Y. Sherman, Julia Yaglom
    Pages 159-168
  8. Cornelia O’Callaghan-Sunol, Vladimir L. Gabai
    Pages 169-190
  9. Cristina Bonorino, Ana Paula Souza
    Pages 191-208
  10. M. Brunet, C. Didelot, S. Subramaniam, A.L. Rérole, A. de Thonel, C. Garrido
    Pages 209-230
  11. Luke Whitesell, Catherine A. McLellan
    Pages 253-274
  12. Adeela Kamal Srinivas Kasibhatla, Marco Biamonte, Hong Zhang, Lin Zhang, Karen Lundgren, Marcus F. Boehm et al.
    Pages 275-294
  13. J.L. Holmes, S.Y. Sharp, P. Workman
    Pages 295-330
  14. Robert Matts, Avrom J. Caplan
    Pages 331-350
  15. Stuart K. Calderwood, Daniel R. Ciocca, Phillip J. Gray, Nava Zaarur, Stan Lepchammer, Michael Y. Sherman
    Pages 351-366
  16. Jianlin Gong, Jimmy R. Theriault, Stuart K. Calderwood
    Pages 367-382
  17. Yasuaki Tamura, Goro Kutomi, Jun Oura, Toshihiko Torigoe, Noriyuki Sato
    Pages 383-396

About this book

Introduction

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Keywords

Anti-cancer vaccine Antigen Cancer therapy Heat shock proteins apoptosis regulation senescence surgery

Editors and affiliations

  • Stuart K. Calderwood
    • 1
  • Michael Y. Sherman
    • 2
  • Daniel R. Ciocca
    • 3
  1. 1.Harvard Medical SchoolBostonU.S.A
  2. 2.Boston University School of MedicineBostonU.S.A
  3. 3.National Research Council CONICETMendozaArgentina

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-6401-2
  • Copyright Information Springer 2007
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4020-6400-5
  • Online ISBN 978-1-4020-6401-2
  • About this book