Evolving Methods for Macromolecular Crystallography

The Structural Path to the Understanding of the Mechanismof Action of CBRN Agents

  • Randy J. Read
  • Joel L. Sussman

Part of the NATO Science Series book series (NAII, volume 245)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Elspeth Garman
    Pages 25-40
  3. Andrew G. W. Leslie, Harold R. Powell
    Pages 41-51
  4. George M. Sheldrick
    Pages 53-65
  5. Airlie J. McCoy, Laurent C. Storoni, Randy J. Read
    Pages 67-77
  6. Nicholas M. Glykos
    Pages 79-90
  7. Randy J. Read, Airlie J. McCoy, Laurent C. Storoni
    Pages 91-100
  8. Tod D. Romo, James C. Sacchettini, Thomas C. Terwilliger, Paul D. Adams, Pavel V. Afonine, Ralf W. Grosse-Kunstleve et al.
    Pages 101-109
  9. Dušan Turk
    Pages 111-122
  10. Vladimir Lunin, Natalia Lunina, Alexandre Urzhumtsev
    Pages 123-133
  11. Aled M. Edwards, James D. Watson, Adel Golovin, Roman A. Laskowski, Kim Henrick, Janet M. Thornton et al.
    Pages 165-179
  12. David Sayre
    Pages 181-191

About these proceedings


This volume comprises papers presented at the 2005 edition of the “Crystallography of Molecular Biology” courses that have been held since 1976 at the Ettore Majorana Centre for Scientific Culture in Erice, Italy. This series of courses is renowned for bringing leaders in the field of macromo- cular crystallography together with highly motivated students, in a beautiful and intimate location that encourages people to interact. The warm and informal atmosphere at these Erice conferences, especially these on cryst- lography, has helped to foster long-term scientific interactions and new int- national friendships that have often lasted for the lifetime of the scientists. The course was financed by NATO as an Advanced Study Institute and by the European Commission as a EuroSummerSchool. The papers span the breadth of material presented in the course, which emphasized the practical aspects of modern macromolecular crystallography and its applications. One must start with crystals: Bergfors showed how to improve initial crystals through seeding, while Byrne discussed the difficult problem of crystallizing membrane proteins. The collection of optimal diffraction data requires both careful preparation of cryo-cooled crystals (Garman) and proper processing of the diffraction images (Leslie). To obtain images of electron density, one needs estimates of the phases of the diffracted spots. Sheldrick presented the background to the sing- wavelength anomalous diffraction (SAD) method, which has been gaining popularity, and McCoy discussed the basis of modern maximum likelihood methods for treating information in experimental phasing.


3D Crystallography X-ray bioinformatics biology genome imaging proteins

Editors and affiliations

  • Randy J. Read
    • 1
  • Joel L. Sussman
    • 2
  1. 1.University of CambridgeUK
  2. 2.Weizmann Institute of ScienceIsrael

Bibliographic information

  • DOI
  • Copyright Information Springer Netherlands 2007
  • Publisher Name Springer, Dordrecht
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-1-4020-6314-5
  • Online ISBN 978-1-4020-6316-9
  • Series Print ISSN 1568-2609
  • Buy this book on publisher's site