Mutagenesis of the Mouse Genome

  • Monica J. Justice
  • Mary Bedell

Table of contents

  1. Front Matter
    Pages i-vii
  2. Monica J. Justice
    Pages 3-7
  3. Miriam H. Meisler, Nicholas W. Plummer, Daniel L. Burgess, David A. Buchner, Leslie K. Sprunger
    Pages 37-45
  4. Sohaila Rastan, Tertius Hough, Amy Kierman, Rachel Hardisty, Alexandra Erven, Ian C. Gray et al.
    Pages 47-49
  5. Amander T. Clark, Daniel Goldowitz, Joseph S. Takahashi, Martha Hotz Vitaterna, Sandra M. Siepka, Luanne L. Peters et al.
    Pages 51-64
  6. David R. Beier, Bruce J. Herron
    Pages 65-69
  7. Molly A. Bogue, Stephen C. Grubb
    Pages 71-74
  8. Mark Strivens, Janan T. Eppig
    Pages 89-97

About this book

Introduction

The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace and mutagenesis is being carried out in many model organisms to discover gene functions. The mouse is the first mammal to be subjected to large-scale mutagenesis, for its biological similarities to the human will permit key discoveries. Mutagenesis of the Mouse Genome focuses on articles relevant to mouse chemical mutagenesis, and is dedicated to the memory of the mutagenesis pioneer, William L. Russell. Monica Justice provides an overview of the history of the Human Genome Project and use of the mouse as the primary organism for the functional annotation of the mammalian genome. With special articles by Jean-Louis Guenet describing the history and development of mouse chemical mutagenesis, Liane Russell analyzing decades of data on DNA damage after chemical treatment, Steven Barthold describing how environment can affect mouse phenotypes, Miriam Meisler summarizing the power of allelic series, Molly Bogue describing the variation in mouse inbred strains, and Mark Strivens and Janan Eppig showing how informatics tools can aid in functional analysis, this book is designed to be a handbook and reference guide for mouse genetics in the post-genome era.

Editors and affiliations

  • Monica J. Justice
    • 1
  • Mary Bedell
  1. 1.Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4020-5057-2
  • Copyright Information Kluwer Academic Publishers 2004
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-2875-5
  • Online ISBN 978-1-4020-5057-2
  • About this book