Bone Metastasis and Molecular Mechanisms


  • Gurmit Singh
  • William Orr

Part of the Cancer Metastasis — Biology and Treatment book series (CMBT, volume 6)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Belinda S. Parker, Bedrich L. Eckhardt, Robin L. Anderson
    Pages 1-18
  3. Julie A. Sharp, Erik W. Thompson
    Pages 19-30
  4. Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr, Gurmit Singh
    Pages 31-48
  5. Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard, Martin Reed, James A. Thliveris, F. William Orr
    Pages 49-69
  6. Paolo Bianco, Mara Riminucci, Pamela Gehron Robey
    Pages 71-85
  7. Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William Orr, Andrew R. Belch
    Pages 109-138
  8. Shafaat A. Rabbani, Nicholas Shukeir, Andrew P. Mazar
    Pages 163-186
  9. Sadmeet Singh, Gurmit Singh
    Pages 187-210
  10. Wilhelmina C. M. Duivenvoorden, Gurmit Singh
    Pages 241-276
  11. Mary MacKenzie, Pierre Major
    Pages 277-301
  12. Back Matter
    Pages 303-308

About this book


Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.


angiogenesis bisphosphonates bone marrow cancer macrophages metastasis pain pathophysiology prostate cancer

Editors and affiliations

  • Gurmit Singh
    • 1
  • William Orr
    • 2
  1. 1.Juravinski Cancer CentreMcMaster UniversityHamiltonCanada
  2. 2.Department of PathologyUniversity of ManitobaWinnipegCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2004
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-6563-6
  • Online ISBN 978-1-4020-2036-0
  • Series Print ISSN 1568-2102
  • Buy this book on publisher's site