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Animal Models of Diabetes

Methods and Protocols

  • Aileen J. F. King
Book

Part of the Methods in Molecular Biology book series (MIMB, volume 2128)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Aileen J. F. King, Lydia F. Daniels Gatward, Matilda R. Kennard
    Pages 1-10
  3. Mototsugu Nagao, Jonathan Lou S. Esguerra, Anna Wendt, Akira Asai, Hitoshi Sugihara, Shinichi Oikawa et al.
    Pages 25-54
  4. Paraskevi Salpea, Cristina Cosentino, Mariana Igoillo-Esteve
    Pages 55-67
  5. Sigurd Lenzen, Tanja Arndt, Matthias Elsner, Dirk Wedekind, Anne Jörns
    Pages 69-85
  6. Dawei Chen, Terri C. Thayer, Li Wen, F. Susan Wong
    Pages 87-92
  7. Gustaf Christoffersson, Malin Flodström-Tullberg
    Pages 93-105
  8. James C. Needell, Danny Zipris
    Pages 107-114
  9. Barbara Ludwig, Eckhard Wolf, Uwe Schönmann, Stefan Ludwig
    Pages 115-134
  10. Aileen J. F. King, Elisabet Estil·les, Eduard Montanya
    Pages 135-147
  11. Lorna I. F. Smith, Thomas G. Hill, James E. Bowe
    Pages 181-205
  12. Patricia Fonseca Pedro, Anastasia Tsakmaki, Gavin A. Bewick
    Pages 207-216
  13. Irene Cózar-Castellano, Germán Perdomo
    Pages 217-224
  14. Aileen J. F. King, Matilda R. Kennard, Manasi Nandi
    Pages 225-239
  15. Patricio Atanes, Inmaculada Ruz-Maldonado, Oladapo E. Olaniru, Shanta J. Persaud
    Pages 241-268
  16. Terri C. Thayer, Dimitri Kakabadse, Joanne Boldison, F. Susan Wong
    Pages 269-289
  17. Irene Cózar-Castellano, Germán Perdomo
    Pages 291-300
  18. Julia K. Panzer, Christian M. Cohrs, Stephan Speier
    Pages 301-312
  19. Back Matter
    Pages 339-342

About this book

Introduction

This volume discusses a variety of animal models of diabetes, as well as describes techniques used to study end-points when using these models. The chapters in this book cover topics such as important considerations when working with mouse models of diabetes, highlighting factors that new investigators may not be aware of and some potential pitfalls in experimental outcomes; main characteristics of some commonly used animal models of diabetes research, ranging from mice to primates; animal models used to study specific aspects of beta-cell biology; and a focus on techniques used to assess blood glucose homeostasis, insulin action, and islet function in vivo and ex vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Animal Models of Diabetes: Methods and Protocols is a valuable resource that will help diabetes researchers design and carry out in vivo studies that will best suit their experimental questions and needs.  

Keywords

Genetically-manipulated animals Humanized mice Phenotypes Glucose homeostasis Biomarkers

Editors and affiliations

  • Aileen J. F. King
    • 1
  1. 1.Department of Diabetes, School of Life Course SciencesKing’s College LondonLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-0716-0385-7
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2020
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-0716-0384-0
  • Online ISBN 978-1-0716-0385-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site