Mitochondrial Dysfunction in Neurodegenerative Disorders

  • Amy Katherine Reeve
  • Kim Jennifer Krishnan
  • Michael R. Duchen
  • Doug M Turnbull

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Mitochondrial Function and Genetics

    1. Front Matter
      Pages 1-1
    2. Amy Katherine Reeve, R. N. Lightowlers
      Pages 3-18
  3. Mitochondrial Dysfunction: Causes and Effects?

    1. Front Matter
      Pages 19-19
    2. Nichola Lax, Evelyn Jaros
      Pages 21-41
    3. Joanna L. Elson, David C. Samuels
      Pages 63-78
    4. Kim Jennifer Krishnan, Amy Katherine Reeve
      Pages 79-91
  4. Functional Consequences of Mitochondrial Dysfunction

    1. Front Matter
      Pages 93-93
    2. Jorge M. A. Oliveira
      Pages 127-139
    3. Talia A. Atkin, Andrew F. MacAskill, Josef T. Kittler
      Pages 157-173
    4. Graham Robert Campbell, Kenneth J. Smith, Don J. Mahad
      Pages 175-190
  5. Modeling Mitochondrial Contribution to Neurodegenerative Disease

    1. Front Matter
      Pages 191-191
    2. Johannes C. Komen, David R. Thorburn
      Pages 193-212
  6. The Future

    1. Front Matter
      Pages 213-213
    2. Claire Henchcliffe, M. Flint Beal
      Pages 215-230
  7. Back Matter
    Pages 231-242

About this book


As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration.


Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.


Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.


clinical research neurodegenaration neurology

Editors and affiliations

  • Amy Katherine Reeve
    • 1
  • Kim Jennifer Krishnan
    • 2
  • Michael R. Duchen
    • 3
  • Doug M Turnbull
    • 4
  1. 1.Institute for Ageing and HealthNewcastle UniversityNewcastle upon TyneUnited Kingdom
  2. 2., Institute for Ageing and HealthNewcastle UniversityNewcastle upon TyneUnited Kingdom
  3. 3., Department of Cell and Developmental BioUniversity College LondonLondonUnited Kingdom
  4. 4., Institute for Ageing and HealthNewcastle UniversityNewcastle upon TyneUnited Kingdom

Bibliographic information