Osteoporosis in Clinical Practice

A Practical Guide for Diagnosis and Treatment

  • Piet Geusens
  • Philip N. Sambrook
  • Robert Lindsay

Table of contents

  1. Front Matter
    Pages i-xxix
  2. General Aspects of Bone, Osteoporosis and Fractures

    1. Front Matter
      Pages 1-1
    2. Philip N. Sambrook, Piet Geusens
      Pages 3-7
    3. Dirk Vanderschueren, Steven Boonen, Roger Bouillon
      Pages 9-14
    4. Lis Mosekilde
      Pages 15-19
    5. Michael R. McClung
      Pages 21-27
    6. Elaine Dennison, Cyrus Cooper
      Pages 29-37
    7. L. Joseph Melton III
      Pages 39-43
  3. Investigations in Osteoporosis

    1. Front Matter
      Pages 45-45
    2. Markus J. Seibel
      Pages 59-67
    3. Kristina Åkesson, Anthony D. Woolf
      Pages 75-86
    4. Carlo Gennari, Stefano Gonnelli
      Pages 87-91
    5. Stephen R. Lord, Hylton B. Menz, Catherine Sherrington
      Pages 93-99
    6. Stuart H. Ralston
      Pages 101-107
  4. Treatment of Postmenopausal Osteoporosis

    1. Front Matter
      Pages 109-109
    2. John C. Stevenson
      Pages 111-118
    3. Steven Boonen, Patrick Haentjens, Dirk Vanderschueren
      Pages 119-127
    4. Robert Lindsay
      Pages 129-132
    5. Piet Geusens, Robert Lindsay
      Pages 143-146
    6. Karl J. Obrant, Olof Johnell
      Pages 147-151
  5. Other Aspects of Osteoporosis

    1. Front Matter
      Pages 153-153
    2. Ego Seeman
      Pages 155-162
    3. Philip N. Sambrook
      Pages 163-169
    4. Jean-Jacques Body
      Pages 171-177
    5. Mehrsheed Sinaki
      Pages 179-185
    6. Peter Burckhardt
      Pages 187-192
    7. Linda Edwards, Kristy Carne
      Pages 193-195
  6. The Future of Diagnosis and Treatment of Osteoporosis

    1. Front Matter
      Pages 197-197
    2. Philip D. Ross, Piet Geusens
      Pages 199-207
    3. Ian R. Reid
      Pages 209-212
    4. Robert P. Heaney
      Pages 213-217
  7. Back Matter
    Pages 219-224

About this book


When I was a young intern in internal medicine,osteoporosis was defined mainly as a fracture occurring in elderly people. However,although plain X-ray examination was recognized as an insensitive way to detect osteoporosis, hypodense bone was already considered as the reflection of the disease. Over the past 20 years, con­ siderable progress has been accomplished. In terms of prevalence, incidence, risk factors, and the burden of osteoporosis and low-energy fracture, we can appreciate the magnitude of the problem and its impact on quality oflife. Weare wellaware that vertebral fracture, which can be acutely associated with a low clinical expression, leads to significant long-term impairments. The costs for the individual and for the health budget, Le. society,are estimated better. Wenow have a clear definition of the disease, such as low bone mass and architectural defects, resulting in increased fragility. For the former part of the definition, the clinician can use accurate and pre­ cise tools allowing them to distinguish how their patient's bone mineral content differs from that of a young healthy population in which fracture occurs very rarely. For the second series of fragility determinants, i. e. structure, methods are in rapid progress and will provide information to clinicians on these variables in the near future. Basicand clinical research have allowed major improvements in the understand­ ing of the pathophysiology of the disease. Newgenes implicated in lowand/or high bone mass have been characterized.


Bone densitometry Differential diagnosis Osteoporosis Tumor biomechanics diagnosis ultrasound

Authors and affiliations

  • Piet Geusens
    • 1
    • 2
  • Philip N. Sambrook
    • 3
  • Robert Lindsay
    • 4
    • 5
  1. 1.Biomedical Research InstituteLimburg University CentreDiepenbeekBelgium
  2. 2.Department of RheumatologyUniversity HospitalMaastrichtThe Netherlands
  3. 3.Institute of Bone and Joint ResearchUniversity of Sydney at Royal North Shore HospitalSydneyAustralia
  4. 4.Pegional Bone CenterHelen Hayes HospitalWest Haverstraw
  5. 5.Columbia University NYUSA

Bibliographic information