Principles of Clinical Cancer Genetics

A Handbook from the Massachusetts General Hospital

  • Daniel C. Chung
  • Daniel A. Haber

Table of contents

  1. Front Matter
    Pages i-xi
  2. Leif W. Ellisen, Daniel A. Haber
    Pages 1-22
  3. Kristen M. Shannon, Devanshi Patel
    Pages 23-40
  4. Paula D. Ryan
    Pages 41-51
  5. Michelle C. Specht, Marcela G. del Carmen, Barbara L. Smith
    Pages 53-62
  6. Andrew T. Chan, Daniel C. Chung
    Pages 63-76
  7. Eunice L. Kwak, Daniel C. Chung
    Pages 77-88
  8. Janivette Alsina, Sarah P. Thayer
    Pages 89-96
  9. Prakash K. Pandalai, Sam S. Yoon
    Pages 97-107
  10. Gayun Chan-Smutko, Othon Iliopoulos
    Pages 109-128
  11. Elizabeth D. Chao, Michele J. Gabree, Hensin Tsao
    Pages 129-144
  12. Yariv J. Houvras, Gilbert H. Daniels
    Pages 145-162
  13. David A. Sweetser, Eric F. Grabowski
    Pages 163-180
  14. Miriam J. Smith, Scott R. Plotkin
    Pages 181-193
  15. Alice T. Shaw, Eyal C. Attar, Edwin Choy, Jeffrey Engelman
    Pages 205-220
  16. Back Matter
    Pages 221-227

About this book


Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed.

In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.


Allele Breast Cancer Cancer Genetics Cancer Screening Colon Cancer Familial Atypical Mole Melanoma Genetic Testing Hap Map Project Multiple Endocrine Neoplasia Ovarian Cancer Pancreatic Cancer Retinoblastom genetics surgery

Editors and affiliations

  • Daniel C. Chung
    • 1
  • Daniel A. Haber
    • 2
  1. 1.Cancer Center and Gastrointestinal Unit, Harvard Medical SchoolMassachusetts General HospitalBostonUSA
  2. 2.Cancer Center, Harvard Medical School andMassachusetts General HospitalBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-0-387-93844-8
  • Online ISBN 978-0-387-93846-2
  • Buy this book on publisher's site