Biophysics of DNA-Protein Interactions

From Single Molecules to Biological Systems

  • Mark C. Williams
  • L. James MaherIII

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages i-x
  2. Binding DNA and Changing its Shape

    1. Front Matter
      Pages 1-1
    2. Daniel Barsky, Ted A. Laurence, Česlovas Venclovas
      Pages 39-68
    3. Ralf Metzler, Bram van den Broek, Gijs J. L. Wuite, Michael A. Lomholt
      Pages 69-84
    4. Gourisankar Ghosh, De-Bin Huang, Tom Huxford
      Pages 85-106
    5. Anjum Ansari, Serguei V. Kuznetsov
      Pages 107-142
  3. Complex Protein-DNA Interactions

    1. Front Matter
      Pages 191-191
    2. Laura Finzi, Carlo Manzo, Chiara Zurla, Haowei Wang, Dale Lewis, Sankar Adhya et al.
      Pages 193-212
    3. Jaylene N. Ollivierre, Michelle C. Silva, Jana Sefcikova, Penny J. Beuning
      Pages 241-292
    4. Claire A. Adams, Manana Melikishvili, Michael G. Fried
      Pages 293-306
    5. Guo Ling Zhou, Li Xin, De Pei Liu
      Pages 325-339
  4. Back Matter
    Pages 341-349

About this book


This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity.


DNA hopping search DNA repair DNA replication DNA sliding search DNA transcription chromatin single molecule biophysics

Editors and affiliations

  • Mark C. Williams
    • 1
  • L. James MaherIII
    • 2
  1. 1.Dept. PhysicsNortheastern UniversityBostonUSA
  2. 2.College of Medicine, Dept. Biochemistry & Molecular BiologyMayo ClinicRochesterUSA

Bibliographic information