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Stem Cells and Cancer

  • Sadhan Majumder

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Stewart Sell
    Pages 1-31
  3. Yuko Fujiwara, Stuart H. Orkin
    Pages 33-60
  4. Sanjay K. Singh, Mohamedi N. Kagalwala, Sadhan Majumder
    Pages 61-89
  5. Leah Owens, Benjamin Tiede, Yibin Kang
    Pages 91-109
  6. Mhairi Copland, Alison M. Michie, Tessa L. Holyoake
    Pages 111-136
  7. Elaine M. Hurt, George J. Klarmann, Brian T. Kawasaki, Nima Sharifi, William L. Farrar
    Pages 137-165
  8. Bert Gold, Michael Dean
    Pages 167-192
  9. Adam Yagui-Beltrán, Biao He, David M. Jablons
    Pages 193-222
  10. Louis Vermeulen, Jan Paul Medema, James C.H. Hardwick, Gijs R. van den Brink
    Pages 223-250
  11. Caterina A. M. La Porta
    Pages 251-267
  12. Nader Sanai, Arturo Alvarez-Buylla
    Pages 269-286
  13. Back Matter
    Pages 287-296

About this book

Introduction

Cancer is a major cause of human morbidity and mortality worldwide. Despite decades of basic and clinical research, the outcome for many cancer patients is still dismal. Although the existence of "stem-like" cells in cancer was hypothesized more than 150 years ago, recent discoveries have the potential to revolutionize cancer therapy. In particular, we now know that many cancers contain a fraction of self-renewing, drug- and radiation-resistant cells (cancer stem cells or cancer-initiating cells) and it is these cells—and not the major bulk of the tissue—that are the root cause for cancer initiation, relapse and metastasis. In a single volume, Stem Cells and Cancer offers up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies across all major types of cancer. It provides timely, cutting-edge information about cancer stem cells from the perspectives of both the basic and clinical sciences.

Keywords

cancer cancer research cancer therapy molecular mechanisms regulation stem cell cancer research stem cell research stem cells

Editors and affiliations

  • Sadhan Majumder

There are no affiliations available

Bibliographic information