Book 2009

Current Hypotheses and Research Milestones in Alzheimer's Disease

Editors:

ISBN: 978-0-387-87994-9 (Print) 978-0-387-87995-6 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix

  2. Amyloid-ß: General Aspects

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 3-12

      Role of Aβ Degrading Enzymes in Synaptic Plasticity and Neurogenesis in Alzheimer’s Disease

    3. No Access

      Chapter

      Pages 13-21

      Pore-Forming Neurotoxin-Like Mechanism for Aβ Oligomer-Induced Synaptic Failure

    4. No Access

      Chapter

      Pages 23-37

      Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells

  3. Neuronal Cytoskeleton and the Tau Hypothesis

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 41-48

      Tau Transgenic Mouse Models in Therapeutic Development

    3. No Access

      Chapter

      Pages 49-62

      What Have We Learned from the Tau Hypothesis?

    4. No Access

      Chapter

      Pages 63-78

      Neuronal Cytoskeleton Regulation and Neurodegeneration

    5. No Access

      Chapter

      Pages 79-91

      Stages of Pathological Tau-Protein Processing in Alzheimer’s Disease: From Soluble Aggregations to Polymerization into Insoluble Tau-PHFs

    6. No Access

      Chapter

      Pages 93-100

      Plasma Membrane-Associated PHF-Core Could be the Trigger for Tau Aggregation in Alzheimer’s Disease

  4. Oxidative Stress Hypothesis

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 103-113

      Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease

  5. Neuroimmunological Hypothesis

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 117-124

      Inflammatory Processes Exacerbate Degenerative Neurological Disorders

    3. No Access

      Chapter

      Pages 125-137

      Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer’s Disease and Their Diagnostic and Therapeutic Implications

    4. No Access

      Chapter

      Pages 139-156

      Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation

  6. Cerebrovascular Pathology and AD

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 159-169

      Cerebral and Cardiac Vascular Pathology in Alzheimer’s Disease

    3. No Access

      Chapter

      Pages 171-180

      Are Amyloids Infectious?

    4. No Access

      Chapter

      Pages 181-188

      The Possible Link Between Herpes Simplex Virus Type 1 Infection and Neurodegeneration

  7. General Aspects of AD Pathogenesis

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 191-204

      Selective Cerebrocortical Regional, Laminar, Modular and Cellular Vulnerability and Sparing in Alzheimer’s Disease: Unexploited Clues to Pathogenesis, Pathophysiology, Molecular- and Systems-Level Hypothesis Generation and Experimental Testing

    3. No Access

      Chapter

      Pages 205-214

      How Biochemical Pathways for Disease May be Triggered by Early-Life Events

  8. Biomarkers and AD

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 217-226

      Strategies for Alzheimer's Disease Diagnosis

  9. Cognitive Neurology in AD

    1. Front Matter

      Pages 1-1

    2. No Access

      Chapter

      Pages 229-236

      The Diagnosis of Dementia in Subjects with Heterogeneous Educational Levels

    3. No Access

      Chapter

      Pages 237-241

      Current Anti-Dementia Drugs: Hypothesis and Clinical Benefits

  10. Back Matter

    Pages 243-247