Molecular Basis of Hematopoiesis

  • Amittha Wickrema
  • Barbara Kee

Table of contents

  1. Front Matter
    Pages i-viii
  2. Patricia Ernst
    Pages 1-22
  3. Robert Mansson, Sasan Zandi, David Bryder, Mikael Sigvardsson
    Pages 23-46
  4. Anne Wilson, Andreas Trumpp
    Pages 47-71
  5. James Palis
    Pages 73-93
  6. Nicholas Papadantonakis, Katya Ravid
    Pages 95-126
  7. Richard Dahl
    Pages 127-149
  8. Benjamin A. Schwarz, Avinash Bhandoola
    Pages 151-172
  9. Steven A. Corfe, Christopher J. Paige
    Pages 173-199
  10. Francesco Colucci
    Pages 201-213
  11. Dominique Bonnet
    Pages 215-230
  12. Back Matter
    Pages 253-257

About this book

Introduction

Although much is known with respect to blood cell formation and function many new concepts in regulation of hematopoietic stem cell commitment and subsequent survival, proliferation and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside (the niche) and commit to distinct blood types has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of micro RNAs in transformation of normal cells into cancer cells. The current volume "Molecular Basis of Hematopoiesis," edited by Amittha Wickrema & Barbara Kee provides the most recent developments in the above mentioned areas in addition to a chapter on utilization of basic science knowledge for treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world working directly in hematopoietic cell research who are pushing the frontiers of biology.  

Keywords

Erythropoiesis Hematopoiesis Leukemic Stem Cells Macrophages Megakaryocytes Regulation Stem Cells T lymphocytes blood diseases influence microRNA function

Editors and affiliations

  • Amittha Wickrema
    • 1
  • Barbara Kee
    • 2
  1. 1.Department of Medicine, MC2115University of ChicagoChicago
  2. 2.Department of Pathology, MC1089University of ChicagoChicago

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-85816-6
  • Copyright Information Springer New York 2009
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-85815-9
  • Online ISBN 978-0-387-85816-6
  • About this book