Current Topics in Complement II

  • John D. Lambris

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 632)

Table of contents

  1. Front Matter
    Pages i-xxx
  2. Robin MacLaren, Wei Cui, Katherine Cianflone
    Pages 1-21
  3. Ricardo J. Komotar, Grace H. Kim, Marc L. Otten, Benjamin Hassid, J. Mocco, Michael E. Sughrue et al.
    Pages 22-32
  4. Kousaku Ohinata, Masaaki Yoshikawa
    Pages 33-44
  5. Mariusz Z. Ratajczak, Marcin Wysoczynski, Ryan Reca, Wu Wan, Ewa K. Zuba-Surma, Magda Kucia et al.
    Pages 45-58
  6. Lawrence L.K. Leung, Toshihiko Nishimura, Timothy Myles
    Pages 59-67
  7. Umme Amara, Daniel Rittirsch, Michael Flierl, Uwe Bruckner, Andreas Klos, Florian Gebhard et al.
    Pages 68-76
  8. Ellinor I.B. Peerschke, Wei Yin, Berhane Ghebrehiwet
    Pages 77-87
  9. Michael A. Flierl, Daniel Rittirsch, J. Vidya Sarma, Markus Huber-Lang, Peter A. Ward
    Pages 88-98
  10. Xiao-Lian Zhang, Mohammed A.M. Ali
    Pages 99-109
  11. Paul N. Barlow, Gregory S. Hageman, Susan M. Lea
    Pages 110-135
  12. Trent M. Woodruff, Kerina J. Costantini, Steve M. Taylor, Peter G. Noakes
    Pages 136-151
  13. Jun Yan, Daniel J. Allendorf, Bing Li, Ruowan Yan, Richard Hansen, Rossen Donev
    Pages 152-167
  14. Michele T. Pritchard, Megan R. McMullen, M. Edward Medof, Abram Stavitsky, Laura E. Nagy
    Pages 168-179
  15. Johan Rönnelid*, Erik Åhlin, Bo Nilsson, Kristina Nilsson-Ekdahl, Linda Mathsson
    Pages 180-194
  16. George Hajishengallis, Min Wang, Shuang Liang, Muhamad-Ali K. Shakhatreh, Deanna James, So-ichiro Nishiyama et al.
    Pages 195-211
  17. Neel K. Krishna, Kenji M. Cunnion
    Pages 228-242
  18. Tom Eirik Mollnes, Dorte Christiansen, Ole-Lars Brekke, Terje Espevik
    Pages 243-253
  19. Erdem Tüzün, Jing Li, Shamsher S. Saini, Huan Yang, Premkumar Christadoss
    Pages 254-261
  20. Daniel Ricklin, John D. Lambris
    Pages 262-281
  21. David C. Fritzinger, Brian E. Hew, June Q. Lee, James Newhouse, Maqsudul Alam, John R. Ciallella et al.
    Pages 282-296
  22. Back Matter
    Pages 309-316

About this book


Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits.

In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.


autoimmune disease bacteria physiology protein virus

Editors and affiliations

  • John D. Lambris

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