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Cyclin Dependent Kinase 5 (Cdk5)

  • Li-Huei Tsai
  • Nancy Y. Ip

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Toshio Ohshima
    Pages 1-8
  3. Yoshio Goshima, Yukio Sasaki, Yutaka Uchida, Naoya Yamashita, Fumio Nakamura
    Pages 9-24
  4. Fan-Yan Wei, Kazuhito Tomizawa
    Pages 25-33
  5. Parvathi Rudrabhatla, Jyotshna Kanungo, Ya-Li Zheng, Niranjana D. Amin, Sashi Kesavapany, Harish C. Pant
    Pages 69-90
  6. Katrin Meuer, Mathias Bähr, Jochen H. Weishaupt
    Pages 91-106
  7. Qian Yang, Zixu Mao
    Pages 107-118
  8. Li Wang, Jie Zhang, Karl Herrup
    Pages 119-137
  9. Yi Wen, Haung Yu, Karen Duff
    Pages 139-144
  10. Christina Bark, Marjan Rupnik, Marko Jevsek, Slavena A. Mandic, Per-Olof Berggren
    Pages 145-158
  11. Gary Kar Ho Ng, Lisheng He, Robert Z. Qi
    Pages 159-170
  12. Shin-ichi Hisanaga, Koichi Ishiguro
    Pages 171-190
  13. Andrea Musacchio
    Pages 191-210
  14. Tej K. Pareek, Ashok B. Kulkarni
    Pages 211-226
  15. Florian Plattner, K. Peter Giese, Marco Angelo
    Pages 227-260
  16. Lit-Fui Lau, Carol D. Hicks
    Pages 283-299
  17. Back Matter
    Pages 301-329

About this book

Introduction

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.

Keywords

Alzheimer Cdk5 Neuron genes migration neurodegenerative diseases proteins regulation signal transduction synaptic plasticity

Editors and affiliations

  • Li-Huei Tsai
  • Nancy Y. Ip

There are no affiliations available

Bibliographic information