Skin Cancer after Organ Transplantation

  • Eggert Stockfleth
  • Claas Ulrich
Book
Part of the Cancer Treatment and Research book series (CTAR, volume 146)

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Introduction – Historical Perspective

    1. Front Matter
      Pages 1-1
    2. Georgios Katsanos, Vincent Donckier
      Pages 1-4
  3. Transplant Medicine

    1. Front Matter
      Pages 9-9
    2. Edward K. Geissler
      Pages 23-43
    3. Jan D. Bos, Rosalie M. Luiten
      Pages 45-62
  4. Post-Transplant Cancer

    1. Front Matter
      Pages 63-63
    2. Charlotte M. Proby, Hermina C. Wisgerhof, Delphine Casabonne, Adele C. Green, Catherine A. Harwood, Jan N. Bouwes Bavinck
      Pages 75-95
    3. Hermina C. Wisgerhof, Jan N. Bouwes Bavinck
      Pages 97-100
    4. Frank R. de Gruijl, Pieter Voskamp
      Pages 101-108
    5. Conal M. Perrett, Catherine A. Harwood, Jane M. McGregor, Peter Karran
      Pages 123-132
    6. Herbert Pfister
      Pages 133-142
    7. Elsemieke I. Plasmeijer, Linda Struijk, Jan N. Bouwes Bavinck, Mariet C.W. Feltkamp
      Pages 143-157
    8. Celeste Lebbé, Camille Francès
      Pages 169-188
    9. Thomas Meyer
      Pages 189-192

About this book

Introduction

Skin Cancer after Organ Transplantation presents the state-of-the-art knowledge of cutaneous malignancies following organ transplantation. The life promoting and life enhancing benefits of solid organ transplantation is a major medical advance, but at the cost of the life-long immunosuppression needed to prevent rejection of the donated organ. This induction and maintenance of impaired immunological surveillance is paralleled by a significant increase in the incidence of specific cancers, of which skin cancers are highest.

The book is divided into four sections, providing a basic overview on transplantation medicine, different immunosuppressive agents and their impact on the skin’s immune system, epidemiology and pathophysiology of skin cancer, applicable prophylaxis and therapeutic measures.

1. Transplant medicine: Addresses the immunological background of organ transplantation, immunosuppression and the impact on the cutaneous immunosurveillance. Different immunosuppressive drugs are presented and their interaction with mechanisms of the cutaneous immunosurveillance against skin cancer, are discussed.

2. Post-transplant skin malignancies: Explores the pathogenesis of transplant skin cancer, epidemiological patterns in different geographical regions, clinical and histological features, etiological factors and molecular events in skin cancer induction and progression, i.e., photocarcinogenesis and UV-induced immunosuppression, and oncogenic viruses like human papillomavirus and human herpesvirus, type 8.

3. Specific skin cancers: Focuses on specific skin cancers in organ transplant recipients, especially the most predominant types, like squamous cell carcinoma, its precursor actinic keratoses, and basal cell carcinoma, but also malignant melanoma, Kaposi’s sarcoma, cutaneous T-cell lymphoma and other, more rare skin malignancies.

4. Prophylaxis and therapies: Experts in the field recommend management strategies for preventing and treating transplant skin cancer, with an emphasis on a multidisciplinary approach. As scientists and clinicians strive together to develop effective chemopreventative agents in the face of this accelerated carcinogenesis, there is a real opportunity for advances in the treatment of transplant skin malignancies to translate into reduced skin cancer in the general population.

"Immunosuppression is an essential component of organ transplantation. Unfortunately, the risk of skin cancer is drastically increased in this setting. Distinguished investigators discuss the cause and therapeutic strategies involving the spectrum of cutaneous malignancies associated with immunosuppression."  Steven T. Rosen, M.D., Series Editor

Keywords

carcinoma cutaneous malignancy epidemiology immunosuppression morbidity organ transplantation pathophyssiology prophylaxis

Editors and affiliations

  • Eggert Stockfleth
    • 1
  • Claas Ulrich
    • 1
  1. 1.Klinik für Dermatologie Venerologie und AllergologieCharité - Universitätsklinikum Berlin Charite Campus Mitte Klinik und Poliklinik for DermatologieGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-78574-5
  • Copyright Information Springer US 2009
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-0-387-78573-8
  • Online ISBN 978-0-387-78574-5
  • Series Print ISSN 0927-3042
  • About this book