Regulatory T Cells and Clinical Application

  • Shuiping Jiang

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Immunobiology of Regulatory T Cells

    1. Front Matter
      Pages 1-1
    2. Karsten Kretschmer, Irina Apostolou, Panos Verginis, Harald von Boehmer
      Pages 17-28
    3. Paola Romagnoli, Julie Ribot, Julie Tellier, Joost P.M. van Meerwijk
      Pages 29-55
    4. Louise M. D’Cruz, Ludger Klein
      Pages 77-89
    5. Yisong Y. Wan, Richard A. Flavell
      Pages 91-109
    6. Natasha R. Locke, Natasha K. Crellin, Megan K. Levings
      Pages 135-152
  3. Regulatory T Cells in Disease and Clinical Application

    1. Front Matter
      Pages 1-1
    2. Ciriaco A. Piccirillo
      Pages 155-198
    3. Adam P. Kohm, Stephen D. Miller
      Pages 253-264
    4. Jonathon Hutton, Clare Baecher-Allan, David A. Hafler
      Pages 265-277
    5. M. Fantini, Markus F. Neurath
      Pages 279-291
    6. Kathryn J Wood, Andrew Bushell, Manuela Carvalho-Gaspar, Gang Feng, Ross Francis, Nick Jones et al.
      Pages 307-323
    7. Herman Waldmann, Elizabeth Adams, Paul Fairchild, Stephen Cobbold
      Pages 325-333

About this book

Introduction

A major process of rediscovery has taken place in the field of Cellular Immunology over the past 12 years—subsets of T lymphocytes exist that are specifically dedicated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses.

It was only after Prof. Sakaguchi identified the CD25 antigen in 1995 as a marker for a major population of T cells that had suppressor functions both in vitro and in vivo that the resurgence in the regulatory T cell area could begin.

The regulatory T cells field has grown dramatically over the past decade. It is now impossible to read a journal that does not contain numerous papers whose titles deal with regulatory T cells. More importantly, it is also difficult to submit a new research grant proposal in any area of immunologic research that does not include a section on analysis on the contribution of regulatory T cells to the subject matter under study.

Regulatory T cells can be best thought of today as "teenagers" ready to take on all the challenges of complex immune responses. In ten years, the field will certainly be more mature, and manipulation of regulatory T cell function by cellular biotherapy, antibodies and small molecules will be routine function of the clinical immunologist.

- From Preface by Prof. Ethan Shevach, National Institute of Health, USA

It has been for long debated whether suppressor/regulatory T cells did actually even exist. Today, this question is no longer accurate and the subject of regulatory T cells is the object of a constantly growing interest in immunologists and clinicians. There is no doubt that the history of Tregs will make a new big leap ahead.

- From Chapter One by Prof. Shimon Sakaguchi, Kyoto University, Japan

Keywords

Asthma T cell Transplantation allergy autoimmune disease cancer cell therapy immune regulation immune tolerance immunology infections infectious disease regulatory t cells transplant tregs

Editors and affiliations

  • Shuiping Jiang

There are no affiliations available

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-77909-6
  • Copyright Information Springer-Verlag New York 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-77908-9
  • Online ISBN 978-0-387-77909-6
  • About this book