Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

  • Alexander A. Vinks
  • Hartmut Derendorf
  • Johan W. Mouton

Table of contents

  1. Front Matter
    Pages i-ix
  2. Basic Concepts and Principles

    1. Front Matter
      Pages 1-1
    2. William A. Craig
      Pages 3-22
    3. William A. Craig
      Pages 23-44
    4. Benjamin Wu, Sherwin K. B. Sy, Hartmut Derendorf
      Pages 63-79
    5. Julia Michael, Aline Barth, Charlotte Kloft, Hartmut Derendorf
      Pages 81-112
    6. Vincent H. Tam
      Pages 135-151
    7. John Turnidge
      Pages 153-198
  3. Clinically Oriented Chapters

    1. Front Matter
      Pages 199-199
    2. Catharine C. Bulik, Charles H. Nightingale, David P. Nicolau
      Pages 201-222
    3. Anouk E. Muller, Johan W. Mouton
      Pages 223-255
    4. Françoise Van Bambeke
      Pages 257-278
    5. Inge C. Gyssens
      Pages 279-322
    6. George L. Drusano, H. S. Heine, A. Louie
      Pages 323-349
    7. Roger L. Nation, Phillip J. Bergen, Jian Li
      Pages 351-380
    8. Céline Vidaillac, Michael J. Rybak
      Pages 381-399
    9. Ursula Theuretzbacher
      Pages 401-443
    10. Catharine C. Bulik, Anthony M. Nicasio, Paul G. Ambrose
      Pages 445-456
  4. Back Matter
    Pages 457-466

About this book


Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development.

Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics  is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.


Antimicrobial Infectious Diseases Pharmacodynamics Pharmacokinetics Pharmacology

Editors and affiliations

  • Alexander A. Vinks
    • 1
  • Hartmut Derendorf
    • 2
  • Johan W. Mouton
    • 3
  1. 1.Division of Clinical PharmacologyCincinnati Children's Hospital Medical CenterCincinnatiUSA
  2. 2.Dept. PharmaceuticsUniversity of Florida, Gainesville College of PharmacyGainesvilleUSA
  3. 3.Dept. of Medical Microbiology, RadboudumcRadboud University NijmegenNijmegenThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-0-387-75612-7
  • Online ISBN 978-0-387-75613-4
  • Buy this book on publisher's site