Acute Neuronal Injury

The Role of Excitotoxic Programmed Cell Death Mechanisms

  • Denson G. Fujikawa

Table of contents

  1. Front Matter
    Pages i-xi
  2. Caspase-Independent Programmed Cell Death: General Considerations

    1. Front Matter
      Pages 1-1
    2. Denson G. Fujikawa
      Pages 1-6
    3. Matthias Rieckher, Nektarios Tavernarakis
      Pages 9-33
    4. Ho Chul Kang, Ted M. Dawson, Valina L. Dawson
      Pages 79-88
  3. Focal Cerebral Ischemia

  4. Transient Global Ischemia

  5. Traumatic Central Nervous System (CNS) Injury

    1. Front Matter
      Pages 156-156
    2. Laurie M. Davis, Patrick G. Sullivan
      Pages 157-168
    3. Bogdan A. Stoica, Alan I. Faden
      Pages 169-200
  6. Hypoglycemic Neuronal Death

    1. Front Matter
      Pages 202-202
    2. Roland N. Auer
      Pages 203-210
    3. Raymond A. Swanson, Sang Won Suh
      Pages 211-228

About this book

Introduction

This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.

Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists.

About the Editor:

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Sta

ff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism, and the Society for Neuroscience.

Keywords

DNA Flow Nervous System Neurology Neuroscience apoptosis caspase-independent mechanisms excitotoxicity necrosis neurons programmed cell death

Editors and affiliations

  • Denson G. Fujikawa
    • 1
  1. 1.Healthcare SystemVA Greater Los AngelesNorth HillsU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-73226-8
  • Copyright Information Springer-Verlag US 2010
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-73225-1
  • Online ISBN 978-0-387-73226-8
  • About this book