Neurochemical Aspects of Excitotoxicity

  • Akhlaq A. Farooqui
  • Wei-Yi Ong
  • Lloyd A. Horrocks

Table of contents

  1. Front Matter
    Pages I-XVII
  2. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 3-20
  3. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 21-35
  4. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 37-49
  5. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 51-74
  6. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 105-136
  7. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 137-160
  8. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 161-203
  9. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 205-240
  10. Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
    Pages 241-260
  11. Back Matter
    Pages 281-290

About this book

Introduction

About 40% of central nervous system synapses use glutamate as the neurotransmitter. Over-stimulation of glutamate receptors produces neuronal injury or death by excitotoxicity, which is closely associated with neurochemical and neuropathological changes involved in acute neural trauma (stroke, spinal cord trauma, and head injury) and neurodegenerative diseases such as Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease, Guam-type amyotrophic lateral sclerosis/Parkinson dementia (ALS/PDC), and multiple sclerosis.

In the past decade, our understanding of the biochemistry, molecular biology, and neuropathology of the glutamate transporters and receptors has exploded. It is becoming increasingly evident that molecular mechanisms, which govern the transfer of the death signal from the neural cell surface to the nucleus, depend on lipid mediators and on cross talk among excitotoxicity, oxidative stress, and neuroinflammation, and that interactions among these three processes play a major role in neuronal cell death during acute neural trauma and neurodegenerative disease. These processes may be primary initiating points in neurodegeneration or they may be the end result of the neurodegenerative process itself.

Neurochemical Aspects of Excitotoxicity provides extensive insight into glutamate transporters and receptors, including their role in the brain with other neurochemical parameters in excitotoxicity, and possible treatments. This book will be of interest to scientists already working in the field of excitotoxicity who are interested in gaining a broader understanding of this complicated subject area, as well as graduate students and neurologists who are curious about a common cause of neuronal injury and neurological disorders.

About the Authors:

Akhlaq A. Farooqui, Wei-Yi Ong, and Lloyd A. Horrocks are leaders in the field of glycerophospholipid metabolism mediated by glutamate in neural membranes. They have reported the stimulation of isoforms of phospholipases A2 caused by glutamate toxicity and increased activities of phospholipases A2 in brains from patients with Alzheimer disease. They have published cutting edge research on kainate-mediated alterations in glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators during excitotoxicity. Akhlaq A. Farooqui and Lloyd A. Horrocks are the authors of the monograph, Glycerophospholipids in the Brain: Phospholipases A2 in Neurological Disorders (Springer 2007). Lloyd A. Horrocks is the founding editor of the journal Molecular and Chemical Neuropathology, and has edited seven other books.

Keywords

Amino acid Aspartat Glutamat Huntington Lipid Nervous System Parkinson aspartate biochemistry glutamate glycerophospholipid metabolism multiple sclerosis neurotoxicity receptor

Authors and affiliations

  • Akhlaq A. Farooqui
    • 1
  • Wei-Yi Ong
    • 2
  • Lloyd A. Horrocks
    • 3
  1. 1.Department of Molecular and Cellular BiochemistryThe Ohio State UniversityColumbusUSA
  2. 2.Department of Anatomy Faculty of MedicineNational University of SingaporeSingapore
  3. 3.The Ohio State UniversityColumbus

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-73023-3
  • Copyright Information Springer Science+Business Media, LLC 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-73022-6
  • Online ISBN 978-0-387-73023-3
  • About this book