Mucosal Immune Defense: Immunoglobulin A

  • Charlotte Slayton Kaetzel

Table of contents

  1. Front Matter
    Pages i-xv
  2. Jenny M. Woof
    Pages 1-24
  3. Jo Spencer, Laurent Boursier, Jonathan D. Edgeworth
    Pages 25-42
  4. Charlotte Slayton Kaetzel, Maria E. C. Bruno
    Pages 43-89
  5. H. Craig Morton
    Pages 90-110
  6. Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg
    Pages 111-143
  7. Michael W. Russell
    Pages 144-172
  8. Armelle Phalipon, Blaise Corthésy
    Pages 183-202
  9. Nicholas J. Mantis, Blaise Corthésy
    Pages 203-220
  10. Per Brandtzaeg, Finn-Eirik Johansen
    Pages 221-268
  11. Dennis W. Metzger
    Pages 269-290
  12. Charu Kaushic, Charles R. Wira
    Pages 291-320
  13. Jiri Mestecky, Lennart Hammarström
    Pages 321-344
  14. Esther M. Yoo, Koteswara R. Chintalacharuvu, Sherie L. Morrison
    Pages 390-415
  15. Back Matter
    Pages 417-433

About this book

Introduction

Antibodies of the IgA class form the front line of immune defense at mucosal surfaces lining the gastrointestinal, respiratory and genital tracts. These IgA antibodies promote peaceful co-existence with beneficial microorganisms, such as gut bacteria that assist in digestion and nutrient production, while selectively neutralizing pathogenic microorganisms and harmful environmental substances. This book, authored by international experts in the field of IgA immunology, presents a comprehensive and timely overview of current knowledge of IgA structure and function. Topics include the basic science of IgA biochemistry and molecular biology, general and tissue-specific aspects of IgA function, and the clinical relevance of IgA in infection, autoimmunity, immunodeficiency and cancer. The final chapters describe state-of-the art applications of molecular genetics for the production of vaccines and therapeutics targeting IgA. The unique focus on IgA, the most abundant molecule in the mucosal immune system, differentiates this book from more general texts in the area of mucosal immunology. This book should be useful for researchers, educators, clinicians and students interested in a concise source of up-to-date information on the central role of IgA in mucosal immune defense.

Keywords

Antigen antibody antimicrobial cell cell culture diseases gene gene regulation immunobiology immunoglobulin pathogenesis polymer research

Editors and affiliations

  • Charlotte Slayton Kaetzel
    • 1
  1. 1.University of KentuckyLexingtonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-72232-0
  • Copyright Information Springer-Verlag US 2007
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-72231-3
  • Online ISBN 978-0-387-72232-0
  • About this book