Mechanisms of Insulin Action

Medical Intelligence Unit

  • Alan R. Saltiel
  • Jeffrey E. Pessin

Table of contents

  1. Front Matter
    Pages i-ix
  2. Pierre De Meyts, Waseem Sajid, Jane Palsgaard, Anne-Mette Theede, Lisbeth Gauguin, Hassan Aladdin et al.
    Pages 1-32
  3. Robert T. Watson, Alan R. Saltiel, Jeffrey E. Pessin, Makoto Kanzaki
    Pages 33-51
  4. Joseph F. Christian, John C. Lawrence Jr.
    Pages 71-89
  5. Catherine Clark, Christopher B. Newgard
    Pages 90-109
  6. Calum Sutherland, Richard M. O’ Brien, Daryl K. Granner
    Pages 110-132
  7. Rohit N. Kulkarni
    Pages 133-151
  8. Silvana Obici, Rossetti Luciano
    Pages 152-167
  9. Francesco Oriente, Domenico Accili
    Pages 168-184
  10. C. Hamish Courtney, Jerrold M. Olefsky
    Pages 185-209
  11. Back Matter
    Pages 211-214

About this book

Introduction

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.

Keywords

Actions Diabetes Diabetes mellitus Insulin Insulin Secretion Mechanisms genes hypertension molecular mechanisms

Authors and affiliations

  • Alan R. Saltiel
    • 1
  • Jeffrey E. Pessin
    • 2
  1. 1.Department of Internal Medicine and Physiology Life Sciences InstituteThe University of Michigan Medical CenterAnn ArborUSA
  2. 2.Department of Pharmacological SciencesState University of New York at Stony BrookStony BrookUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-72204-7
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2007
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-0-387-72203-0
  • Online ISBN 978-0-387-72204-7
  • About this book