An Integrative Approach From Science to Medicine

  • William D. Figg
  • Judah Folkman

Table of contents

  1. Front Matter
    Pages i-xix
  2. Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process

    1. Judah Folkman
      Pages 1-14
    2. M. Luisa Iruela-Arispe
      Pages 35-43
    3. Liliana Guedez, William G. Stetler-Stevenson
      Pages 55-62
    4. Alireza S. Alavi, David A. Cheresh
      Pages 63-73
  3. Angiogenesis and Regulatory Proteins

    1. Marco Presta, Stefania Mitola, Patrizia Dell'Era, Daria Leali, Stefania Nicoli, Emanuela Moroni et al.
      Pages 77-88
    2. Andrius Kazlauskas
      Pages 99-111
    3. Pipsa Saharinen, Lauri Eklund, Kari Alitalo
      Pages 113-120
    4. Michael B. Duncan, Raghu Kalluri
      Pages 121-127
  4. Molecular & Cellular Mechanisms of the Angiogenic Process

    1. Domenico Ribatti, Angelo Vacca
      Pages 161-168
    2. Philip J. S. Charlesworth, Adrian L. Harris
      Pages 169-179
    3. Donald P. Bottaro, Nelly Tan, W. Marston Linehan
      Pages 181-191
    4. L. Morbidelli, S. Donnini, M. Ziche
      Pages 193-204
    5. Harukiyo Kawamura, Xiujuan Li, Michael Welsh, Lena Claesson-Welsh
      Pages 205-216
    6. Gavin Thurston, Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly, John S. Rudge, Nicholas W. Gale et al.
      Pages 217-224
    7. Michele De Palma, Lisa M. Coussens
      Pages 225-237
    8. Marco Seandel, Andrea T. Hooper, Shahin Rafii
      Pages 239-248
    9. Chris Folkins, Robert S. Kerbel
      Pages 249-258
    10. Isaiah J. Fidler, Cheryl Hunt Baker, Kenji Yokoi, Toshio Kuwai, Toru Nakamura, Monique Nilsson et al.
      Pages 259-270
  5. Functional Assessments of Angiogenesis

    1. Rakesh K. Jain, Dan G. Duda, Tracy T. Batchelor, A. Gregory Sorensen, Christopher G. Willett
      Pages 273-281
    2. Robert Auerbach
      Pages 299-312
    3. Sylvia S. W. Ng, Kim N. Chi
      Pages 313-320
    4. Tristan Barrett, Peter L. Choyke
      Pages 321-332
    5. Janine Stevens, Brad St. Croix
      Pages 333-342
  6. Clinical Translation of Angiogenesis Inhibitors

    1. Napoleone Ferrara
      Pages 345-352
    2. Kristina M. Cook, Christopher J. Schofield
      Pages 359-373
    3. Jeanny B. Aragon-Ching, Ravi A. Madan, James L. Gulley
      Pages 375-385
    4. Cindy H. Chau, William Dahut, William D. Figg
      Pages 387-394
    5. Hagit Mann-Steinberg, Ronit Satchi-Fainaro
      Pages 395-414
    6. John S. Rudge, Ella Ioffe, Jingtai Cao, Nick Papadopoulos, Gavin Thurston, Stanley J. Wiegand et al.
      Pages 415-420
    7. Cindy H. Chau, William D. Figg
      Pages 421-430
    8. Chien-Fu Hung, Archana Monie, T. -C. Wu
      Pages 451-460
    9. Roberta Sarmiento, Raffaele Longo, Giampietro Gasparini
      Pages 461-475
    10. Guido Bocci, Giuseppe Pasqualetti, Antonello Di Paolo, Mario Del Tacca, Romano Danesi
      Pages 477-486
  7. Angiogenesis in Health & Disease

    1. Carmen Ruiz de Almodovar, Serena Zacchigna, Peter Carmeliet
      Pages 489-504
    2. Leah N. Cueni, Michael Detmar
      Pages 505-516
    3. Peter A. Campochiaro
      Pages 517-531
    4. Luisa A. DiPietro
      Pages 533-539
    5. Thomas K. Hunt, Michael Gimbel, Chandan K. Sen
      Pages 541-559
    6. Julie M. D. Paye, Chohreh Partovian, Michael Simons
      Pages 561-573
  8. Back Matter
    Pages 585-601

About this book


Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases.

This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters.

Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.


angiogenesis cell biology endothelium imaging regulation surgery tumor growth

Editors and affiliations

  • William D. Figg
    • 1
  • Judah Folkman
    • 2
  1. 1.Center for Cancer ResearchNational Cancer InstituteBethesdaUSA
  2. 2.Department of Surgery Harvard Medical School and Vascular Biology ProgramChildren's Hospital BostonBostonUSA

Bibliographic information