Genetically Engineered Mice for Cancer Research

design, analysis, pathways, validation and pre-clinical testing

  • Jeffrey E. Green
  • Thomas Ried

Table of contents

  1. Front Matter
    Pages i-xx
  2. Thomas Doetschman, L. Philip Sanford
    Pages 1-15
  3. Yi Li, Andrea Ferris, Brian C. Lewis, Sandra Orsulic, Bart O. Williams, Eric C. Holland et al.
    Pages 83-111
  4. Bart M. G. Smits, Edwin Cuppen, Michael N. Gould
    Pages 113-131
  5. Jennifer A. Prescher, Christopher H. Contag
    Pages 235-260
  6. Andrew O. Giacomelli, Robin M. Hallett, John A. Hassell
    Pages 261-279
  7. Hosein Kouros-Mehr
    Pages 281-292
  8. Melanie Kucherlapati, Ken Hung, Mari Kuraguchi, Raju Kucherlapati
    Pages 309-329
  9. Richard Marcotte, William J. Muller
    Pages 331-352
  10. Lauren Reinke, Ming Zhang
    Pages 353-373
  11. Cecilia Rosales, Manel Esteller
    Pages 375-396
  12. Veronica R. Placencio, Neil A. Bhowmick
    Pages 397-415

About this book

Introduction

Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.

Keywords

Insertional Mutagenesis maspin p53 pRB tyrosine kinases

Editors and affiliations

  • Jeffrey E. Green
    • 1
  • Thomas Ried
    • 2
  1. 1., Laboratory Of Cancer Biology and GeneticNational Cancer InstituteBethesdaUSA
  2. 2.National Cancer Institute, Center for Cancer ResearchNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-69805-2
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-69803-8
  • Online ISBN 978-0-387-69805-2
  • About this book