Modern Molecular Biology

Approaches for Unbiased Discovery in Cancer Research

  • Srinivasan Yegnasubramanian
  • William B. Isaacs

Table of contents

  1. Front Matter
    Pages i-xi
  2. Srinivasan Yegnasubramanian, William B. Isaacs
    Pages 13-31
  3. Srinivasan Yegnasubramanian, William G. Nelson
    Pages 47-66
  4. Jun Luo, Yidong Chen
    Pages 67-85
  5. Biaoyang Lin, Jeremy Wechsler, Leroy Hood
    Pages 87-115
  6. Mohamad A. Abbani, Parag Mallick, Maryann S. Vogelsang
    Pages 117-156
  7. Toby C. Cornish, Angelo M. De Marzo
    Pages 157-184
  8. Back Matter
    Pages 185-189

About this book


A convergence of advancements in molecular biology, engineering, computer science, biostatistics and other disciplines has made possible the development of technologies facilitating the massively parallel investigation of the complex biological phenomena driving cancer initiation and progression. Such technologies include DNA microarrays, next generation sequencing, proteomics technologies, and tissue microarrays. In order to properly harness these technologies to imaginatively decipher these complex biological processes, scientists must have an understanding of the underlying technology, be able to adapt these technologies with molecular biology lab approaches, and then be poised to efficiently process and interpret the extremely high dimensional and complex data sets that are generated by these technologies. The primary purpose of this volume is to help bridge the gap between molecular biologists and cancer researchers and the bioinformatics and computational biology researchers by providing an overview of these technologies to those that are not yet familiar with them.


Computerassistierte Detektion DNA Microarray Proteomics bioinformatics diagnosis gene expression genes genome molecular biology tissue

Editors and affiliations

  • Srinivasan Yegnasubramanian
    • 1
  • William B. Isaacs
    • 2
  1. 1.Sidney Kimmel Comprehensive, Cancer CenterJohns Hopkins UniversityBaltimoreUSA
  2. 2.School of Medicine, Urology, Pharmacology, OncologyJohns Hopkins UniversityBaltimoreUSA

Bibliographic information