Androgen Action in Prostate Cancer

  • Editors
  • James Mohler
  • Donald Tindall

Table of contents

  1. Front Matter
    Pages i-viii
  2. The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer

    1. Front Matter
      Pages 8-8
    2. Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka
      Pages 9-55
    3. Mark Pomerantz, Philip Kantoff
      Pages 57-72
    4. Shuyuan Yeh, Yuanjie Niu, Hiroshi Miyamoto, Tamin Chang, Chawnshang Chang
      Pages 73-89
    5. Michael Carey, Lily Wu
      Pages 91-120
  3. Androgen Metabolism

  4. Androgen Receptor Structure/Function Relationships

    1. Front Matter
      Pages 206-206
    2. Grant Buchanan, Eleanor F. Need, Tina Bianco-Miotto, Norman M. Greenberg, Howard I. Scher, Margaret M. Centenera et al.
      Pages 207-240
    3. Elizabeth M. Wilson
      Pages 241-267
    4. Eva Estébanez-Perpiñá, Robert J. Fletterick
      Pages 297-311
  5. Co-Regulators of the Androgen Receptor

    1. Front Matter
      Pages 314-314
    2. Latif A. Wafa, Robert Snoek, Paul S. Rennie
      Pages 341-374

About this book

Introduction

This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800’s, and then awareness reawakened in the 1940’s by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966.

The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.

Keywords

DNA Drogen gene expression genes imaging transcription

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-69179-4
  • Copyright Information Springer-Verlag New York 2009
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-69177-0
  • Online ISBN 978-0-387-69179-4
  • About this book