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Androgen Action in Prostate Cancer

  • Editors
  • James Mohler
  • Donald Tindall

Table of contents

  1. Front Matter
    Pages i-viii
  2. The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer

    1. Front Matter
      Pages 8-8
    2. Shutsung Liao, John M. Kokontis, Chih-Pin Chuu, Richard A. Hiipakka
      Pages 9-55
    3. Mark Pomerantz, Philip Kantoff
      Pages 57-72
    4. Shuyuan Yeh, Yuanjie Niu, Hiroshi Miyamoto, Tamin Chang, Chawnshang Chang
      Pages 73-89
    5. Michael Carey, Lily Wu
      Pages 91-120
  3. Androgen Metabolism

  4. Androgen Receptor Structure/Function Relationships

    1. Front Matter
      Pages 206-206
    2. Grant Buchanan, Eleanor F. Need, Tina Bianco-Miotto, Norman M. Greenberg, Howard I. Scher, Margaret M. Centenera et al.
      Pages 207-240
    3. Elizabeth M. Wilson
      Pages 241-267
    4. Eva Estébanez-Perpiñá, Robert J. Fletterick
      Pages 297-311
  5. Co-Regulators of the Androgen Receptor

    1. Front Matter
      Pages 314-314
    2. Latif A. Wafa, Robert Snoek, Paul S. Rennie
      Pages 341-374
    3. F. Claessens, T. Tanner, A. Haelens
      Pages 385-404
    4. Li Jia, Omar Khalid, Baruch Frenkel, Gerhard A. Coetzee
      Pages 405-424
  6. Ligand-Independent Activation of the Androgen Receptor

    1. Front Matter
      Pages 426-426
    2. Scott M. Dehm, Donald J. Tindall
      Pages 427-449
    3. Zoran Culig, Alfred Hobisch
      Pages 451-463
  7. Role of the Androgen Receptor in Prostate Cancer during Castration

    1. Front Matter
      Pages 506-506
    2. Clifford G. Tepper, Hsing-Jien Kung
      Pages 507-551
    3. James L. Mohler, Mark A. Titus
      Pages 553-568
    4. David J. DeGraff, Xiuping Yu, Qian Sun, Janni Mirosevich, Ren Jie Jin, Yongqing Wang et al.
      Pages 587-615
  8. Androgen-Regulated Genes during Prostate Cancer Progression

    1. Front Matter
      Pages 618-618
    2. Donald J. J. Vander Griend, John T. Isaacs
      Pages 619-630
    3. Nigel Clegg, Peter S. Nelson
      Pages 631-661
    4. Qianben Wang, Myles Brown
      Pages 663-680
    5. Tanya K. Day, Colleen C. Nelson, Martin E. Gleave
      Pages 681-700
    6. Rou Wang, Scott A. Tomlins, Arul M. Chinnaiyan
      Pages 701-721
    7. Johannes V. Swinnen, Koen Brusselmans, Hannelore V. Heemers, Guido Verhoeven
      Pages 723-739
  9. The Androgen Receptor as a Drugable Target

    1. Front Matter
      Pages 742-742
    2. Nagalakshmi Nadiminty, Allen C. Gao
      Pages 755-780
  10. Back Matter
    Pages 781-799

About this book

Introduction

This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800’s, and then awareness reawakened in the 1940’s by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966.

The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.

Keywords

DNA Drogen gene expression genes imaging transcription

Bibliographic information