Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

  • Patrick Augustijns
  • Marcus E. Brewster

Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume VI)

Table of contents

  1. Front Matter
    Pages I-IX
  2. YUCHUAN GONG, DAVID J.W. GRANT, HARRY G. BRITTAIN
    Pages 1-27
  3. JONATHAN M. MILLER, NAÍR RODRÍGUEZ-HORNEDO, ANTHONY C. BLACKBURN, DAINIUS MACIKENAS, BENJAMIN M. COLLMAN
    Pages 53-109
  4. LI DI, EDWARD H. KERNS
    Pages 111-136
  5. ANETTE MüLLERTZ
    Pages 151-177
  6. FRANÇOISE INGELS, ANNA-LENA UNGELL, PATRICK AUGUSTIJNS
    Pages 179-220
  7. MARCUS E. BREWSTER, CLAIRE MACKIE, MARC NOPPE, ANN LAMPO, THORSTEINN LOFTSSON
    Pages 221-256
  8. ROBERT G. STRICKLEY, REZA OLIYAI
    Pages 257-308
  9. ERIK MOGALIAN, PAUL BRIAN MYRDAL
    Pages 427-441
  10. Back Matter
    Pages 443-465

About this book

Introduction

Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.

Keywords

Augustijns Biopharmaceutics Brewster Pharmaceutics Solvent Systems selection

Editors and affiliations

  • Patrick Augustijns
    • 1
  • Marcus E. Brewster
    • 2
  1. 1.Catholic University of LeuvenBelgium
  2. 2.Janssen Pharmaceutica N.V.BeerseBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-69154-1
  • Copyright Information Springer 2007
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-69149-7
  • Online ISBN 978-0-387-69154-1
  • About this book