Modulation of Protein Stability in Cancer Therapy

  • Editors
  • Eric Rubin
  • Kathleen Sakamoto

Table of contents

  1. Front Matter
    Pages i-x
  2. Angelika M. Burger, Arun K. Seth
    Pages 1-18
  3. Christopher L. Brooks, Wei Gu
    Pages 31-43
  4. William Y. Kim, William G. Kaelin Jr.
    Pages 45-63
  5. Patricia McChesney, Gary M. Kupfer
    Pages 65-80
  6. Pooja Pungaliya, Eric Rubin
    Pages 81-97
  7. Marie Wehenkel, Yik Khuan Ho, Kyung-Bo Kim
    Pages 99-119
  8. Carmen Priolo, Derek Oldridge, Martin Renatus, Massimo Loda
    Pages 121-146
  9. Agustin Rodriguez-Gonzalez, Kathleen M. Sakamoto
    Pages 147-160
  10. Back Matter
    Pages 161-165

About this book


This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer.  The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome.  Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed.  Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.


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Bibliographic information