© 2008

Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal

  • Dmitry I. Gabrilovich
  • Arthur A. Hurwitz

Table of contents

  1. Front Matter
    Pages I-IX
  2. Silvia Piconese, Mario P. Colombo
    Pages 41-67
  3. Michael R. Shurin, Gurkamal S. Chatta
    Pages 101-130
  4. Suzanne Ostrand-Rosenberg, Pratima Sinha
    Pages 131-155
  5. Paolo Serafini, Vincenzo Bronte
    Pages 157-195
  6. Ildefonso Vicente-Suarez, Alejandro Villagra, Eduardo M. Sotomayor
    Pages 197-218
  7. Paulo C. Rodríguez, Augusto C. Ochoa
    Pages 219-233
  8. Alex Corzo, Srinivas Nagaraj, Dmitry I. Gabrilovich
    Pages 259-280
  9. Bin Zhang, Donald A. Rowley, Hans Schreiber
    Pages 281-294
  10. Back Matter
    Pages 295-301

About this book


Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on:

  • Different surface molecules that mediate T-cell suppression in cancer;
  • The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness;
  • The contribution of regulatory T cells in the inability of immune systems to mount antitumor response;
  • The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression.

This volume connects a multitude of different immunosuppressive mechanisms into one cohesive picture. Most of the chapters not only describe the biological phenomena, but also suggest specific approaches to their correction.

This book should be of high interest for researchers in the fields of tumor immunology and general immunology, as well as for those who are involved in clinical oncology and cancer immunotherapy.


Antigen B7-H1/PD-1 Dendritic Cells Immune Suppressive Mechanisms Macrophages T Cell Tumor Development apoptosis cancer immunobiology inhibitory pathway molecular mechanisms regulation

Editors and affiliations

  • Dmitry I. Gabrilovich
    • 1
  • Arthur A. Hurwitz
    • 2
  1. 1.H. Lee Moffitt Cancer CenterUniversity of South FloridaTampaUSA
  2. 2.Laboratory of Molecular ImmunoregulationNational Cancer InstituteFrederickUSA

Bibliographic information


From the reviews:

"The overall goal of this book is to describe what is currently known about the ways tumors circumvent destruction by the host’s immune system. … The book is targeted at researchers -- immunologists in general and, more specifically, tumor immunologists. It also provides a good source of information for graduate students and postdoctoral fellows. The editors of the book and the authors of the chapters are authorities in the areas they discuss. … a useful addition to the field." (Marion C. Cohen, Doody’s Review Service, August, 2008)