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The Kinetochore:

From Molecular Discoveries to Cancer Therapy

  • Peter De Wulf
  • William C. Earnshaw

Table of contents

  1. Front Matter
    Pages 1-11
  2. Mitsuhiro Yanagida
    Pages 1-24
  3. Beth A. Sullivan
    Pages 1-32
  4. Owen J. Marshall, K.H Andy Choo
    Pages 1-30
  5. Tatsuo Fukagawa, Peter De Wulf
    Pages 1-59
  6. Paul B. Talbert, Joshua J. Bayes, Steven Henikoff
    Pages 1-37
  7. Rebecca Heald, Claire E. Walczak
    Pages 1-38
  8. Lesley Clayton, Tomoyuki U. Tanaka
    Pages 1-24
  9. Chitra V. Kotwaliwale, Sue Biggins
    Pages 1-51
  10. P. Todd Stukenberg, Daniel J. Burke
    Pages 1-26
  11. Scott Thomas, Kenneth B. Kaplan
    Pages 1-24
  12. Takeshi Tomonaga
    Pages 1-22
  13. Song-Tao Liu, Tim J. Yen
    Pages 1-25
  14. Back Matter
    Pages 1-29

About this book

Introduction

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

Keywords

Chromosom DNA Evolution cell division cytokinesis eukaryotic chromosome functional analysis kinetochores neocentromeres post-translational modification proteins regulation tissue translation tumorogenesis

Editors and affiliations

  • Peter De Wulf
    • 1
  • William C. Earnshaw
    • 2
  1. 1.Dipto. Oncologia SperimentaleIstituto Europeo di OncologiaMilanoItaly
  2. 2.Animal & Population Biology, Inst. Cell & Molecular BiologyUniversity of EdinburghEdinburghUnited Kingdom

Bibliographic information