The Cancer Degradome

Proteases and Cancer Biology

  • Dylan Edwards
  • Gunilla Høyer-Hansen
  • Francesco Blasi
  • Bonnie F. Sloane

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. The Degradome and Its Analysis

    1. Xose S. Puente, Gonzalo R. Ordóñez, Carlos López-Otín
      Pages 3-15
    2. Caroline J. Pennington, Robert K. Nuttall, Clara Sampieri-Ramirez, Matthew Wallard, Simon Pilgrim, Dylan R. Edwards
      Pages 49-65
    3. Mari Enoksson, Wenhong Zhu, Guy S. Salvesen
      Pages 67-82
    4. Anna Prudova, Ulrich auf dem Keller, Christopher M. Overall
      Pages 83-100
    5. Vincent Dive, Margot G. Paulick, J. Oliver McIntyre, Lynn M. Matrisian, Matthew Bogyo
      Pages 101-135
    6. Kamiar Moin, Mansoureh Sameni, Christopher Jedeszko, Quanwen Li, Mary B. Olive, Raymond R. Mattingly et al.
      Pages 137-154
  3. Insights into Protease Function

    1. Nesrine I. Affara, Lisa M. Coussens
      Pages 157-182
    2. Kasper Almholt, Anna Juncker-Jensen, Kirsty Anne Green, Helene Solberg, Leif Røge Lund, John Rømer
      Pages 203-221
    3. Silvia D’Alessio, Francesco Blasi
      Pages 223-243
    4. Thore Hillig, Lars H. Engelholm, Niels Behrendt
      Pages 245-258
    5. Thomas Reinheckel, Vasilena Gocheva, Christoph Peters, Johanna A. Joyce
      Pages 281-304
    6. Sarah Berndt, Françoise Bruyère, Maud Jost, Agnès Noël
      Pages 305-325
    7. Maud Jost, Silvia Vosseler, Silvia Blacher, Norbert E. Fusenig, Margareta M. Mueller, Agnès Noël
      Pages 327-342
    8. Kumari L. Andarawewa, Marie-Christine Rio
      Pages 361-372
    9. Aditya Murthy, William Cruz-Munoz, Rama Khokha
      Pages 373-400
  4. The Interface Between Proteolysis and Cell Signalling

    1. Susette C. Mueller, Vira V. Artym, Thomas Kelly
      Pages 403-431
    2. Pia Ragno, Francesco Blasi
      Pages 433-450
    3. Moreno Zamai, Gabriele Malengo, Valeria R. Caiolfa
      Pages 475-493
    4. Jennifer H. Cox, Christopher M. Overall
      Pages 519-539
    5. Conor C. Lynch, Lynn M. Matrisian
      Pages 541-566
  5. The Degradome as Source of Cancer Diagnostic and Markers

    1. Ib Jarle Christensen, Helle Pappot, Gunilla Høyer-Hansen
      Pages 569-586
    2. Tamara T. Lah, Nataša Obermajer, María Beatriz Durán Alonso, Janko Kos
      Pages 587-625
    3. Caroline J. Pennington, Simon Pilgrim, Paul N. Span, Fred C. Sweep, Dylan R. Edwards
      Pages 627-643
    4. Kristiina Iljin, Sami Kilpinen, Johanna Ivaska, Olli Kallioniemi
      Pages 645-661
    5. Ross Laxton, Shu Ye
      Pages 663-677
    6. Camilla Frederiksen, Anne Fog Lomholt, Hans Jørgen Nielsen, Nils Brünner
      Pages 679-696
  6. Novel Therapeutic Strategies

    1. Benedikte Jacobsen, Magnus Kjaergaard, Henrik Gårdsvoll, Michael Ploug
      Pages 699-719
    2. M. Patrizia Stoppelli, Lisbeth M. Andersen, Giuseppina Votta, Peter A. Andreasen
      Pages 721-758
    3. Hideaki Nagase, Gillian Murphy
      Pages 787-810
    4. Gregg B. Fields
      Pages 827-851
    5. Risto Ala-aho, Andrew H. Baker, Veli-Matti Kähäri
      Pages 877-894
  7. Back Matter
    Pages 895-926

About this book


Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.


CLIP-CHIP Microarray PCR angiogenesis cysteine cathepsin degradome gene expression genes imaging mass spectrometry migration plasminogen regulation tissue transplantation

Editors and affiliations

  • Dylan Edwards
    • 1
  • Gunilla Høyer-Hansen
    • 2
  • Francesco Blasi
    • 3
  • Bonnie F. Sloane
    • 4
  1. 1.School of Biological SciencesUniversity of East AngliaNorwichUK
  2. 2.Finsen LaboratoryCopenhagen BiocenterCopenhagen NDenmark
  3. 3.Università Vita Salute San Raffaele and IFOM (Fondazione Istituto FIRC di Oncologia Molecolare)MilanItaly
  4. 4.Wayne State UniversityDetroitUSA

Bibliographic information