Microarray Technology and Cancer Gene Profiling

  • Simone Mocellin

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 593)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Microarray Technology

    1. David W. Petersen, Ernest S. Kawasaki
      Pages 1-11
    2. Simone Mocellin, Carlo Riccardo Rossi
      Pages 19-30
    3. Ernst Wit, Vilda Purutcuoglu, Lucy O’Donovan, Ximin Zhu
      Pages 31-38
    4. Ena Wang, Monica Panelli, Francesco M. Marincola
      Pages 39-53
    5. Giovanni Esposito
      Pages 54-65
    6. Maurizio Provenzano, Simone Mocellin
      Pages 66-73
  3. Applications in the Oncology Field

    1. Ainhoa Perez-Diez, Andrey Morgun, Natalia Shulzhenko
      Pages 74-85
    2. Vladia Monsurrò, Francesco M. Marincola
      Pages 86-94
    3. Lu Wang, Robert Luhm, Ming Lei
      Pages 105-116
    4. Mei He, Jennifer Rosen, David Mangiameli, Steven K. Libutti
      Pages 117-133
    5. Sarah E. Henrickson, Elena M. Hartmann, German Ott, Andreas Rosenwald
      Pages 134-146
    6. Simone Mocellin, Mario Lise, Donato Nitti
      Pages 147-156
  4. Back Matter
    Pages 157-159

About this book

Introduction

Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.

Keywords

DNA Microarray PCR SNP Tumor classification gene expression genes genome

Editors and affiliations

  • Simone Mocellin
    • 1
  1. 1.Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e ChirurgicheUniversity of PadovaPadovaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-39978-2
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2007
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-39977-5
  • Online ISBN 978-0-387-39978-2
  • Series Print ISSN 0065-2598
  • About this book