Protein Misfolding, Aggregation, and Conformational Diseases

Part B: Molecular Mechanisms of Conformational Diseases

  • Vladimir N. Uversky
  • Anthony L. Fink

Part of the Protein Reviews book series (PRON, volume 6)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Altered Protein Structure and Enhanced Aggregation/Deposition

    1. Front Matter
      Pages 1-1
    2. Aβ-Protein and Alzheimer’s Disease

      1. Liana G. Apostolova, Jeffrey L. Cummings
        Pages 3-29
      2. Kevin J. Barnham, Cyril C. Curtain, Ashley I. Bush
        Pages 31-47
    3. β-Synuclein and Parkinson’s Disease

    4. Prion Protein and Prion Diseases

      1. Giuseppe Legname, Stephen J. DeArmond, Fred E. Cohen, Stanley B. Prusiner
        Pages 125-146
      2. Ilia V. Baskakov
        Pages 147-163
      3. Joanna Krzewska, Ronald Melki
        Pages 165-182
      4. Marina Ramirez-Alvarado, Janelle K. De Stigter, Elizabeth M. Baden, Laura A. Sikkink, Richard W. McLaughlin, Anya L. Taboas
        Pages 183-197
      5. Anne Clark, Jenni Moffitt
        Pages 199-216
      6. Isobel J. Morten, Eric W. Hewitt, Sheena E. Radford
        Pages 217-239
      7. Zafer Ali-Khan
        Pages 241-256
  3. Point Mutations and Enhanced Protein Deposition

    1. Front Matter
      Pages 257-257
    2. Joel N. Buxbaum
      Pages 259-283
    3. Mireille Dumoulin, Russell J. K. Johnson, Vittorio Bellotti, Christopher M. Dobson
      Pages 285-308
  4. Altered Protein Structure and Impaired Function

  5. Changes in Supramolecular Structure

    1. Front Matter
      Pages 363-363
    2. Mariz Vainzof, Mayana Zatz
      Pages 391-407
    3. Roger John Willis Truscott
      Pages 435-447
  6. Altered Protein Structure and Changes in Cellular/Nuclear Function

    1. Front Matter
      Pages 449-449
    2. Victor M. Miller, Henry L. Paulson
      Pages 465-479
    3. Erica S. Chevalier-Larsen, Diane E. Merry
      Pages 481-495
  7. Post-Translational Modification and Protein Conformational Diseases

    1. Front Matter
      Pages 497-497
  8. Back Matter
    Pages 527-537

About this book


Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is a comprehensive volume providing a broad and detailed discussion of the relationships of protein misfolding and aggregation with the pathogenesis of numerous conformational diseases. While the Part A was dedicated to the description of the general mechanisms underlying protein misfolding, aggregation, and development of protein deposition disorders, this volume summarizes recent achievements in the understanding of the molecular mechanisms of conformational diseases. Research indicates that these mechanisms are highly diverse and range from the altered protein structure leading to the enhanced propensity for aggregation/deposition or the impaired functions and ending with changes in supra-molecular structures or posttranslational modification. Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is an ideal book for pharmaceutical scientists, molecular and cellular biologists, biochemists, immunologists, protein scientists, and biophysicists.


cell biology molecular mechanisms pathophysiology physiology post-translational modification protein structure translation

Editors and affiliations

  • Vladimir N. Uversky
    • 1
    • 2
  • Anthony L. Fink
    • 3
  1. 1.Department of Biochemistry and Molecular Biology, Center for Computational Biology and BioinformaticsIndiana University School of MedicineIndianapolis
  2. 2.Institute for Biological InstrumentationRussian Academy of SciencesPushchino, Moscow RegionRussia
  3. 3.Department of Chemistry and BiochemistryUniversity of CaliforniaSanta CruzUSA

Bibliographic information