Complex Systems Science in Biomedicine

  • Thomas S. Deisboeck
  • J. Yasha Kresh

Table of contents

  1. Front Matter
    Pages i-xix
  2. Introduction

  3. Complex Systems Science: The Basics

    1. Front Matter
      Pages 31-31
    2. Joshua E. S. Socolar
      Pages 115-140
    3. Van M. Savage, Geoffrey B. West
      Pages 141-163
    4. Stefan Wuchty, Erszébet Ravasz, Albert-László Barabási
      Pages 165-181
  4. Complex Adaptive Biosystems: A Multi-Scaled Approach

    1. Front Matter
      Pages 207-207
    2. Complexity in Molecular Networks

      1. Juan M. Pedraza, Alexander van Oudenaarden
        Pages 211-226
      2. Ivo L. Hofacker, Peter F. Stadler
        Pages 227-245
      3. Andreas Wagner
        Pages 247-263
    3. The Cell as a Complex System

    4. Developmental Biology and The Cardiac System

      1. Raimond L. Winslow
        Pages 375-407
    5. The Immune System

    6. The Nervous System

      1. George N. Reeke Jr.
        Pages 463-482
      2. Florian P. Kolb, Dagmar Timmann
        Pages 507-533
    7. Cancer: A Systems Approach

      1. Ricard V. Solé, Isabel González García, José Costa
        Pages 557-572
      2. Yuri Mansury, Thomas S. Deisboeck
        Pages 573-602
    8. The Interaction of Complex Biosystems

      1. Steve W. Cole
        Pages 605-629
      2. Lewis A. Lipsitz
        Pages 641-654
  5. Enabling Technologies

    1. Front Matter
      Pages 655-655
    2. Steve Wereley, Carl Meinhart
      Pages 657-677
    3. Mohammad R. Kaazempur-Mofrad, Eli J. Weinberg, Jeffrey T. Borenstein, Joseph P. Vacanti
      Pages 737-761
    4. David P. M. Northmore, John Moses, John G. Elias
      Pages 811-826
    5. Frank Kirchner, Dirk Spenneberg
      Pages 827-836
  6. Back Matter
    Pages 849-864

About this book


Complex Systems Science in Biomedicine
Thomas S. Deisboeck and J. Yasha Kresh

Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts.    
In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure.  The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science.
Key Topics Include:
• Historic Perspectives of General Systems Thinking
• Fundamental Methods and Techniques for Studying Complex Dynamical Systems
• Applications from Molecular Networks to Disease Processes
• Enabling Technologies for Exploration of  Systems in the Life Sciences

Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field.  

About the Editors:
Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging.

J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.


Nervous System biomedical engineering biomedical imaging biomedicine complex system complex systems development dynamics imaging medicine radiology surgery tissue

Editors and affiliations

  • Thomas S. Deisboeck
    • 1
  • J. Yasha Kresh
    • 2
    • 3
  1. 1.Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical ImagingMassachusetts General HospitalCharlestown
  2. 2.Dept. of Cardiothoracic SurgeryDrexel Univ. College of MedicinePhiladelphia
  3. 3.Cardiovascular BiophysicsDrexel Univ. College of MedicinePhiladelphia

Bibliographic information