• V. Daniel Castracane
  • Michael C. Henson

Part of the Endocrine Updates book series (ENDO, volume 25)

Table of contents

  1. Front Matter
    Pages i-xv
  2. V. Daniel Castracane, Michael C. Henson
    Pages 1-9
  3. Laura C. Schulz, Eric P. Widmaier
    Pages 11-31
  4. Lauren N. Bell, Robert V. Considine
    Pages 33-51
  5. Abhiram Sahu
    Pages 53-77
  6. Asha Thomas-Geevarghese, Robert Ratner
    Pages 79-101
  7. Robert V. Considine
    Pages 103-123
  8. Giuseppe Matarese, Claudio Procaccini, Veronica De Rosa
    Pages 125-138
  9. Michael C. Henson, V.Daniel Castracane
    Pages 149-182
  10. Delia-Marina Alexe, Eleni Petridou
    Pages 201-223
  11. Rexford S. Ahima, Malaka B. Jackson
    Pages 225-245
  12. Luciana Ribeiro, João Vicente Busnello, Julio Licínio
    Pages 247-262
  13. C. Richard Barb, Gary J. Hausman, Timothy G. Ramsay
    Pages 263-308
  14. Jehangir Mistry
    Pages 319-326
  15. Elif Ariogly Oral, Alex M. DePaoli
    Pages 327-359
  16. Back Matter
    Pages 361-371

About this book


The discovery of leptin little more than a decade ago, as a hormone produced in white adipose tissue with an important role in satiety and energy expenditure, was a seminal event in our understanding of adiposity. This initial advance in the new endocrinology of obesity was soon followed by the realization that leptin was not only produced in adipose tissue, but in many different tissues of the body, and that receptors were similarly distributed. Additionally, the early recognition of infertility that was associated with leptin deficiency prompted research that identified roles for the polypeptide in virtually every area of reproductive biology.

A general interest in leptin has rapidly produced inroads into unexpected areas of physiology that may eventually elucidate the varied relationships of adiposity to human health and disease. These developments have been paralleled by a rigorous investigation as a product of pharmaceutical interest. The broad range of physiology and the clinical situations in which leptin is now implicated is reviewed for the first time in the present volume.


***Series Editor's comments****

This volume integrates cutting edge basic and clinical information encompassing the expression of leptin and leptin receptors, pathophysiology and clinical role of leptin- a new neuroendocrine hormone with pleiotropic roles in appetite regulation, metabolic, inflammatory, neoplastic, cardiovascular and reproductive functions.

This single volume encyclopedic coverage is indispensable to students, postdoctoral trainees, fellows, scientists and practitioners interested in neuroendocrine peptide control of multiple cellular functions.

Shlomo Melmed, M.D.
Series Editor
Endocrine Updates



bone hormone leptin receptors metabolism neuroendocrinology obesity physiology protein reproduction

Editors and affiliations

  • V. Daniel Castracane
    • 1
    • 2
  • Michael C. Henson
    • 3
    • 4
  1. 1.Texas Tech University School of MedicineLubbockUSA
  2. 2.Foundation for Blood ResearchScarboroughUSA
  3. 3.Department of Biological SciencesPurdue University CalumetHammondUSA
  4. 4.Dept. of Obstetrics and Gynecology, School of MedicineTulane University Health SciencesNew OrleansUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2007
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-0-387-31415-0
  • Online ISBN 978-0-387-31416-7
  • Series Print ISSN 1566-0729
  • Buy this book on publisher's site