New Concepts of Antiviral Therapy

  • Andreas Holzenburg
  • Elke Bogner

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Concepts of therapy for RNA viruses

    1. Front Matter
      Pages 1-1
    2. Michael Roggendorf, Mengji Lu
      Pages 3-20
    3. Ernst Kuechler, Joachim Seipelt
      Pages 87-114
    4. Stephan Pleschka, Stephan Ludwig, Thorsten Wolff, Oliver Planz
      Pages 115-167
    5. Justin Stebbing, Mark Bower, Brian Gazzard
      Pages 189-212
    6. Jaqueline D. Reeves, Stephen D. Barr, Stephan Pöhlmann
      Pages 213-254
    7. Barbara Schmidt, Monika Tschoschner, Hauke Walter, Klaus Korn
      Pages 255-279
  3. Concepts of therapy for DNA viruses

    1. Front Matter
      Pages 282-282
    2. Johan Neyts, Erik de Clercq
      Pages 283-307
    3. John C. Drach, Leroy B. Townsend, Elke Bogner
      Pages 337-349
  4. Concepts of therapy for emerging viruses

    1. Front Matter
      Pages 396-396
    2. Jens H. Kuhn, Sheli R. Radoshitzky, Wenhui Li, Swee Kee Wong, Hyeryun Choe, Michael Farzan
      Pages 397-418
  5. General concepts of therapy

    1. Front Matter
      Pages 454-454
    2. Armin Ensser
      Pages 507-532
  6. Back Matter
    Pages 533-538

About this book


Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA).

Highlights of this book include the discussion of:

- novel, promising compounds

- concepts of therapy for new/emerging viruses

- managing drug resistance

- new therapeutic strategies

This book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.


HIV Hepatitis Virus antiviral drug antiviral targets infection infections medical microbiology siRNA therapies viral infection virology

Editors and affiliations

  • Andreas Holzenburg
    • 1
  • Elke Bogner
    • 2
  1. 1.Texas A&M UniversityMicroscopy and Imaging CentreCollege StationUSA
  2. 2.Institut für Molekulare und Klinische VirologieUniversität Erlangen-NürnbergGermany

Bibliographic information