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Multichain Immune Recognition Receptor Signaling

From Spatiotemporal Organization to Human Disease

  • Alexander B. Sigalov
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 640)

Table of contents

  1. Front Matter
    Pages i-xxvii
    PDF

  2. MIRRs: Structure and Physiological Function

    1. T-Cell Receptor
      Jose M. Rojo, Raquel Bello, Pilar Portolés
      Pages 1-11
    2. B-Cell Receptor
      Randall J. Brezski, John G. Monroe
      Pages 12-21
    3. Fc Receptors
      Maree S. Powell, P. Mark Hogarth
      Pages 22-34
    4. Natural Killer Cell Receptors
      Roberto Biassoni
      Pages 35-52
    5. Platelet Glycoprotein VI
      Stephanie M. Jung, Masaaki Moroi
      Pages 53-63

  3. MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize

    1. Clustering Models
      Wolfgang W.A. Schamel, Michael Reth
      Pages 64-73
    2. Segregation Models
      Elaine P. Dopfer, Mahima Swamy, Gabrielle M. Siegers, Eszter Molnar, Jianying Yang, Wolfgang W. A. Schamel
      Pages 74-81
    3. Kinetic Proofreading Model
      Byron Goldstein, Daniel Coombs, James R. Faeder, William S. Hlavacek
      Pages 82-94
    4. Serial Triggering Model
      Jacob Rachmilewitz
      Pages 95-102
    5. Conformational Model
      Ruth M. Risueño, Angel R. Ortiz, Balbino Alarcón
      Pages 103-112
    6. Permissive Geometry Model
      Susana Minguet, Wolfgang W.A. Schamel
      Pages 113-120
    7. Signaling Chain Homooligomerization (SCHOOL) Model
      Alexander B. Sigalov
      Pages 121-163
    8. Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses
      Michael L. Dustin
      Pages 164-182
    9. Visualization of Protein Interactions in Living Cells
      Tomasz Zal
      Pages 183-197

  4. MIRR Signaling and Therapy of Immune Disorders

    1. Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences
      Darja Kanduc
      Pages 198-207
    2. Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides
      Nicholas Manolios, Marina Ali, Michael Amon, Veronika Bender
      Pages 208-219
    3. Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer
      Akira Nakamura, Tomohiro Kubo, Toshiyuki Takai
      Pages 220-233
    4. Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease
      Joseph R. Podojil, Danielle M. Turley, Stephen D. Miller
      Pages 234-251
    5. MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines
      Vasso Apostolopoulos, Eliada Lazoura, Minmin Yu
      Pages 252-267
    6. SCHOOL Model and New Targeting Strategies
      Alexander B. Sigalov
      Pages 268-311
      PDF
    7. Immune Receptor Signaling, Aging and Autoimmunity
      Anis Larbi, Tamas Fülöp, Graham Pawelec
      Pages 312-324
    8. Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment
      Walter M. Kim, Alexander B. Sigalov
      Pages 325-349
      PDF
  5. Back Matter
    Pages 351-357
    PDF

About this book

Keywords

Antigen Disease Human Immune Multichain Receptor Recognition Sigalov Signaling Spatiotemporal autoimmune disease

Editors and affiliations

  • Alexander B. Sigalov
    • 1
  1. 1.Department of PathologyUniversity of Massachusetts Medical SchoolWorcesterUSA

Bibliographic information