Physiology and Disease

  • Michael E.┬áMaragoudakis
  • Nikos E.┬áTsopanoglou

Table of contents

  1. Front Matter
    Pages i-xii
  2. Enrico Di Cera*, Andras Gruber
    Pages 1-18
  3. Rithwik Ramachandran, Mahmoud El-Daly, Mahmoud Saifeddine, Morley D. Hollenberg*
    Pages 19-46
  4. Martin Moser, Cam Patterson*
    Pages 81-92
  5. Nikos E. Tsopanoglou*, Michael E. Maragoudakis
    Pages 93-113
  6. Barbara Olszewska-Pazdrak, John S. Bergmann, Gerald M. Fuller, Darrell H. Carney
    Pages 115-132
  7. Weibo Luo, Yingfei Wang, Georg Reiser*
    Pages 133-159
  8. Boris Kobrinsky*, Simon Karpatkin*
    Pages 161-172
  9. Zaidoun Salah, Sorina Grisaru-Granovsky, Myriam Maoz, Beatrice Uziely, Irit Cohen, Hagit Turm et al.
    Pages 173-188
  10. Gloria A. Petralia*, Ajay K. Kakkar
    Pages 189-203
  11. Cailin Chen*, Bruce E. Maryanoff*, Patricia Andrade-Gordon
    Pages 205-236
  12. Back Matter
    Pages 259-266

About this book


It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets."


APC PAR Thrombin biochemistry cells endothelium enzymes physiology proteins receptor signaling sphingosine-1 tissue tumor biology vascular development vascular physiology

Editors and affiliations

  • Michael E.┬áMaragoudakis
    • 1
  • Nikos E.┬áTsopanoglou
    • 1
  1. 1.Medical SchoolUniversity of PatrasPatrasGreece

Bibliographic information