Retroviruses and Insights into Cancer

  • Jaquelin¬†Dudley

Table of contents

  1. Front Matter
    Pages i-xii
  2. Naomi Rosenberg
    Pages 1-30
  3. Karen L. Beemon, Mohan Bolisetty
    Pages 31-52
  4. Sandra K. Ruscetti, Joan L. Cmarik
    Pages 53-94
  5. Chioma M. Okeoma, Susan R. Ross
    Pages 95-118
  6. Jaquelin P. Dudley, Jennifer A. Mertz, Sanchita Bhadra, Massimo Palmarini, Christine A. Kozak
    Pages 119-162
  7. Sandra L. Quackenbush, James W. Casey, Paul R. Bowser, Joel Rovnak
    Pages 191-218
  8. Melanie R. Rutkowski, William R. Green
    Pages 219-258
  9. James C. Neil, Monica A. Stewart
    Pages 285-305
  10. Maribeth V. Eiden, Dwayne L. Taliaferro
    Pages 307-333
  11. Back Matter
    Pages 335-363

About this book

Introduction

Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.

Keywords

Oncogenesis Retrovirology

Editors and affiliations

  • Jaquelin¬†Dudley
    • 1
  1. 1., Section of Molecular Genetics and MicrobUniversity of Texas, AustinAustinUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-387-09581-3
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-09580-6
  • Online ISBN 978-0-387-09581-3
  • About this book