Genetics of Colorectal Cancer

  • John D. Potter
  • Noralane M. Lindor

Part of the Cancer Genetics book series (CANGENETICS)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Epidemiology and Models of Colorectal Cancer

    1. John D. Potter, David Hunter
      Pages 5-25
    2. Erin M. Perchiniak, Joanna Groden
      Pages 27-49
  3. Pathways to Colorectal Cancer

  4. Germline Susceptibility – Mendelian and Other Syndromes

    1. Julian A. Sanchez, Graham Casey, James M. Church
      Pages 125-139
    2. Brittany C. Thomas, Matthew J. Ferber, Noralane M. Lindor
      Pages 141-169
    3. Spring Holter, Steven Gallinger
      Pages 173-181
    4. Additional Syndromes with Hereditary Predisposition to Colorectal Cancer

      1. Noralane M. Lindor
        Pages 183-186
      2. Joanne P. Young
        Pages 187-191
      3. Douglas L. Riegert-Johnson, Lisa A. Boardman
        Pages 193-198
      4. Kara A. Mensink, Jeremy R. Jass, Noralane M. Lindor
        Pages 199-205
      5. Beatriz Russell, Joanna Groden
        Pages 207-212
      6. Serena Masciari, Sapna Syngal
        Pages 213-217
  5. Germline Susceptibility – Gene-Environment Interactions

    1. Elizabeth M. Poole, James T. Cross, John D. Potter, Cornelia M. Ulrich
      Pages 243-260
    2. Roberd M. Bostick, Michael Goodman, Eduard Sidelnikov
      Pages 277-298
  6. Back Matter
    Pages 299-309

About this book


The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, MYH-Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. Genetics of Colorectal Cancer provides the most up-to-date information in each of these areas.


Cancer Chromosom DNA Epidemiology genes genetics molecular epidemiology

Editors and affiliations

  • John D. Potter
    • 1
  • Noralane M. Lindor
    • 2
  1. 1.Member and Senior Advisor Fred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Department of Medical GeneticsMayo Clinic College of MedicineRochesterUSA

Bibliographic information