© 1997

Annual Reports in Combinatorial Chemistry and Molecular Diversity

  • W. H. Moos
  • M. R. Pavia
  • B. K. Kay
  • A. D. Ellington

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Combinatorial Chemistry

    1. Front Matter
      Pages 1-1
    2. Michael R. Pavia
      Pages 3-5
    3. John S. Kiely
      Pages 6-18
    4. Sepehr Sarshar, Adnan M. M. Mjalli
      Pages 19-29
    5. Steven E. Hall
      Pages 30-40
    6. Diane M. Coe, Richard Storer
      Pages 50-58
    7. Sheila H. DeWitt
      Pages 69-77
  3. Combinatorial Biology and Evolution

    1. Front Matter
      Pages 91-91
    2. Brian K. Kay, Andrew D. Ellington
      Pages 93-94
    3. Peter Schuster
      Pages 153-168
    4. Sulay D. Jhaveri, Ichiro Hirao, Sabine Bell, Kyle W. Uphoff, Andrew D. Ellington
      Pages 169-191
    5. Zhan-Gong Zhao, Kit S. Lam
      Pages 192-209
    6. John Collins
      Pages 210-262
  4. Informatics and Related Topics

    1. Front Matter
      Pages 263-263
    2. Walter H. Moos
      Pages 265-266

About this book


Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research.
This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.


Compound biology chemistry drug discovery mutation nucleic acid organic synthesis pharmaceutical synthesis

Editors and affiliations

  • W. H. Moos
    • 1
  • M. R. Pavia
    • 2
  • B. K. Kay
    • 3
  • A. D. Ellington
    • 4
  1. 1.MitoKorSan DiegoUSA
  2. 2.Sphinx PharmaceuticalsCambridgeUSA
  3. 3.University of North CarolinaChapel HillUSA
  4. 4.Indiana UniversityBloomingtonUSA

Bibliographic information

  • Book Title Annual Reports in Combinatorial Chemistry and Molecular Diversity
  • Editors W.H. Moos
    M.R. Pavia
    B.K. Kay
    Andrew D. Ellington
  • Series Title Annual Reports in Combinatorial Chemistry and Molecular Diversity
  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1997
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-90-72199-23-2
  • Softcover ISBN 978-94-017-0738-1
  • eBook ISBN 978-0-306-46904-6
  • Series ISSN 1384-2811
  • Edition Number 1
  • Number of Pages XIII, 354
  • Number of Illustrations 54 b/w illustrations, 3 illustrations in colour
  • Topics Pharmacy
    Biochemistry, general
    Organic Chemistry
    Polymer Sciences
  • Buy this book on publisher's site