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Erythropoietins and Erythropoiesis

Molecular, Cellular, Preclinical, and Clinical Biology

  • Graham Molineux
  • Mary Ann Foote
  • Steven G. Elliott

Part of the Milestones in Drug Therapy MDT book series (MDT)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Background and basic science

    1. Front Matter
      Pages 1-1
    2. Lyonel G. Israels, Esther D. Israels
      Pages 3-14
    3. Timothy Osslund, Rashid Syed
      Pages 25-34
    4. Saghi Ghaffari, Lily Jun-shen Huang, Jing Zhang, Harvey F. Lodish
      Pages 65-85
    5. Anne C. Heatherington
      Pages 87-112
    6. Graham Molineux
      Pages 113-132
    7. Alice S. Chuck, Rohini R. Deshpande, Adrian R. Distler, Shane A. Sander, James E. Seely
      Pages 133-150
  3. Clinical use of recombinant erythropoietins

    1. Front Matter
      Pages 151-151
    2. Fred D. Cushner
      Pages 197-204
    3. Don H. Catlin, Caroline K. Hatton, Françoise Lasne
      Pages 205-227
    4. Patrick Mayeux, Nicole Casadevall
      Pages 229-239
  4. Back Matter
    Pages 259-269

About this book

Introduction

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene. In the years subsequent to the cloning of EPO and its expression as a recombinant protein, much was written about EPO. Although much has been learned and published, new, exciting data are becoming ava- able on almost a daily basis. Erythropoietins and Erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology compiles both pertinent historical and very recent research on this molecule and its clinical utility. The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.

Keywords

anemia antibody biology biotechnology blood cell cancer cell clinical research erythropoietin gene protein receptor signaling research signal transduction tissue

Editors and affiliations

  • Graham Molineux
    • 1
  • Mary Ann Foote
    • 1
  • Steven G. Elliott
    • 1
  1. 1.Amgen IncThousand OaksUSA

Bibliographic information