NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

  • Zofia Zukowska
  • Giora Z. Feuerstein

Part of the Experientia Supplementum book series (EXS, volume 95)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Introduction

  3. NPY family of peptides, receptors and processing enzymes

    1. Front Matter
      Pages 5-5
    2. Nicole Merten, Annette G. Beck-Sickinger
      Pages 35-62
  4. Physiological and pathophysiological perspectives of the NPY family of peptides

    1. Front Matter
      Pages 63-63
    2. M. Verónica Donoso, Ana María Delpiano, J. Pablo Huidobro-Toro
      Pages 65-76
    3. Lars Edvinsson
      Pages 105-112
    4. Joseph Winaver, Zaid Abassi
      Pages 123-132
    5. L. Christine Turtzo, M. Daniel Lane
      Pages 133-141
    6. Douglas J. MacNeil, Akio Kanatani
      Pages 143-156
    7. Susan J. Allison, Herbert Herzog
      Pages 171-182
    8. Annika Thorsell, Rose-Marie Karlsson, Markus Heilig
      Pages 183-192
    9. Mary Ann Dutton, Edward W. Lee, Zofia Zukowska
      Pages 213-222
    10. Carol A. Colton, Michael P. Vitek
      Pages 223-244
  5. Genetics of the NPY family of peptides and their receptors

    1. Front Matter
      Pages 245-245
  6. Summary

    1. Front Matter
      Pages 269-269
  7. Back Matter
    Pages 273-280

About this book


The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.

The ideal complement to this volume is the book NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer, recently published by the same editors in the Birkhäuser book series Progress in Inflammation Research. Both volumes together give a comprehensive overview of the NPY family of peptides.



biology circulation diseases endothelium genes homeostasis metabolic disorder metabolism molecular biology neurobiology obesity peptides pharmacology receptor sympathetic control

Editors and affiliations

  • Zofia Zukowska
    • 1
  • Giora Z. Feuerstein
    • 2
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical CenterWashington, DCUSA
  2. 2.Wyeth ResearchCollegevilleUSA

Bibliographic information