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Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

  • Annika B. Malmberg
  • Keith R. Bley

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Historical perspective on capsaicin and its receptor

    1. János Szolcsányi
      Pages 3-22
  3. Molecular and cellular properties of vanilloid receptors

    1. Janet Winter
      Pages 39-51
  4. Pharmacology and physiology of vanilloid receptors

    1. Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets, Larry V. Pearce
      Pages 55-69
    2. Zoltán Sándor, Arpad Szallasi
      Pages 95-115
  5. Vanilloid receptor involvement in disease states

    1. Maria G. Belvisi, Peter J. Barnes
      Pages 167-187
  6. Therapeutic potential of vanilloid agonists and antagonists

    1. Keith R. Bley, Annika B. Malmberg
      Pages 191-209
    2. Francisco Cruz, Carlos Silva, Paulo Dinis
      Pages 211-225
    3. Kenneth J. Valenzano, James D. Pomonis, Katharine Walker
      Pages 227-243
  7. Back Matter
    Pages 245-252

About this book

Introduction

Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.

Keywords

Activation analgesics cannabinoid diseases drug drug development inflammation lead muscle neurons pain pharmacology physiology regulation treatment

Editors and affiliations

  • Annika B. Malmberg
    • 1
  • Keith R. Bley
    • 2
  1. 1.Elan PharmaceuticalsSouth San FranciscoUSA
  2. 2.NeurogesX, Inc.San CarlosUSA

Bibliographic information

  • DOI https://doi.org/10.1007/3-7643-7379-2
  • Copyright Information Birkhäuser Verlag 2005
  • Publisher Name Birkhäuser Basel
  • eBook Packages Medicine
  • Print ISBN 978-3-7643-7080-0
  • Online ISBN 978-3-7643-7379-5
  • Buy this book on publisher's site