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Biosynthesis

Aromatic Polyketides, Isoprenoids, Alkaloids

  • Finian J. Leeper
  • John C. Vederas

Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 209)

Table of contents

  1. Front Matter
    Pages I-X
  2. Robert M. Williams, Emily M. Stocking, Juan F. Sanz-Cervera
    Pages 97-173
  3. Thomas Hemscheidt
    Pages 175-206
  4. Back Matter
    Pages 245-247

About this book

Introduction

This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). Volume 1 covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.

Keywords

Alkaloide Biochemie Biochemistry Biosynthese Organische Chemie alcaloids biosynthesis enzymes metabolism natural product organic chemistry

Editors and affiliations

  • Finian J. Leeper
    • 1
  • John C. Vederas
    • 2
  1. 1.Department of ChemistryUniversity of CambridgeCambridgeGreat Britain
  2. 2.Department of ChemistryUniversity of AlbertaEdmontonCanada

Bibliographic information

  • DOI https://doi.org/10.1007/3-540-48146-X
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-66573-1
  • Online ISBN 978-3-540-48146-1
  • Series Print ISSN 0340-1022
  • Buy this book on publisher's site